随着互联网的快速发展，青少年网络游戏障碍（IGD）问题逐渐凸显，IGD对他们的身体和心理健康造成了严重危害,且戒断和治疗难度较大。2019年，世界卫生组织（WHO）更是将游戏障碍（gaming disorder，GD）正式列入诊断范畴，并纳入《国际疾病分类》第11版。在我国，青少年网民数量已接近2亿，IGD患者数量较大，亟需在关于IGD的认知及治疗上取得突破。国内外研究表明，IGD对青少年的心身伤害与前额叶、边缘系统、纹状体等结构的异常激活及功能连接损害有关，进而造成神经认知障碍，执行功能障碍，情绪调节困难，奖惩反馈异常，行为异常等功能障碍。因此，本文中我们旨在通过对近年来IGD的研究文献进行系统性的综述，借助神经生理影像学的研究手段，整体梳理IGD对青少年大脑结构和功能的改变,以提升对该疾病病理生理改变的认识，进一步辅助临床诊疗应用及研究设计。 

With the rapid development of the Internet, the problem of internet gaming disorder (IGD) among adolescents has gradually become prominent. IGD has caused serious harm to their physical and mental health, and it is difficult to withdraw and treat. In 2019, the World Health Organization (WHO) officially listed Gaming Disorder (GD) in the diagnostic category and included it in the 11th edition of the International Classification of Diseases. In China, the number of adolescent internet users has approached 200 million, and the number of IGD patients is relatively large. It is urgent to make breakthroughs in the cognition and treatment of IGD. Domestic and foreign studies have shown that IGD’s physical and psychological harm to adolescents is related to the abnormal activation and functional connection damage of structures such as the prefrontal lobe, limbic system, and striatum, which in turn causes neurocognitive disorders, executive dysfunction, difficulty in emotional regulation, abnormal reward and punishment feedback, behavioral abnormalities and other functional disorders; therefore, this article aims to systematically review the research literature on IGD in recent years, and use neurophysiological imaging research method  to sort out the changes in the brain structure and function of adolescents with IGD, in order to improve the understanding of the pathophysiology of the disease, and assist in further clinical diagnosis, treatment, application and research design.