目的 探讨人体手背皮肤组织中组织液流动通道的微观结构。    方法   纳入7例死亡12 h内的新鲜遗体，利用MRI观察手指第1指节到手腕的组织液流动分布，精准定位流动通路，并基于影像学结果进行组织学分析，明确流动通道的组织学性质；进一步结合多重免疫荧光和微计算机断层扫描技术(Micro-CT)对流动通道分析，通过图像后处理从微观结构层面阐明流动通路的解剖学结构。    结果  在手部标本示指第1指节注射造影剂并反复按压后，MRI成像发现组织液向心性长程流动，其路径与血管、淋巴管不同；组织学分析、Micro-CT进一步证实，这种流动主要发生在皮肤纤维结缔组织和血管外膜中。    结论  皮肤中有序的纤维结缔组织、血管外膜共同构成了人体手背皮肤组织中的组织液流动通道，即基质膜通道。

Objective To investigate the anatomical and microscopic structures of interstitial fluid flow channels in the skin tissue of hand dorsum in human cadavers.  Methods  Totally 7 fresh cadavers within 12 hours post-mortem were included. MRI was used to observe the distribution of interstitial fluid flow from the first phalanx of the fingers to the wrist, precisely locating the flow channels. Based on imaging results, histological analyses were conducted to determine the histological characteristics of the flow channels. Furthermore, multi-immunofluorescence and microcomputed tomography (Micro-CT) techniques were employed to analyze the channels, and image post-processing was used to elucidate their anatomical structures at the microscopic level.   Results  After injecting a contrast agent into the first phalanx of ten finger specimens and applying repeated pressure, MRI image revealed centripetal long-range interstitial fluid flow along channels distinct from blood vessels and lymphatic vessels. Histological analysis and Micro-CT further confirmed that the flow primarily occurred within the fibrous connective tissue and adventitia of the skin.   Conclusion  The orderly fibrous connective tissue and adventitia in the skin form the interstitial fluid flow channels in the human hand dorsum skin, named as “stromal membrane channels” in the skin.