DHH基因单核苷酸多态性与抑郁症的相关分析

陈婧婕  王艺羲  梁鹏  李悦  李健  梁芸丹

doi:10.16098/j.issn.0529-1356.2025.02.005

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解剖学报 ›› 2025, Vol. 56 ›› Issue (2) : 158-162. DOI: 10.16098/j.issn.0529-1356.2025.02.005

神经生物学

DHH基因单核苷酸多态性与抑郁症的相关分析

陈婧婕¹王艺羲² 梁鹏¹ 李悦¹ 李健^1* 梁芸丹^1*

作者信息 +

Association analysis of DHH gene single nucleotide polymorphism and depression

CHEN Jing-jie¹ WANG Yi-xi² LIANG Peng¹ LI Yue¹ LI Jian^1* LIANG Yun-dan^1*

Author information +

文章历史 +

摘要

目的探讨DHH基因的rs7296288单核苷酸多态性(SNP)与抑郁症发病的相关性。方法收集2018年3月~2019年12月期间在四川省人民医院、济宁市精神病院、云南省精神卫生中心3家医院480例抑郁症患者作为病例组，329例非抑郁症作为对照组，采集外周血样本，提取血液中DNA，采用多重扩增和高通量测序技术对DHH基因rs7296288进行基因分型，并用统计学方法对抑郁症进行相关性分析。结果 DHH基因的rs7296288多态位点AA型在对照组为32.9%，病例组为36.7%；AC基因型在对照组为52.8%，病例组为47.7%；CC基因型在对照组为14.3%，病例组为15.6%。共显性、显性、隐性统计学模型均无统计学意义。通过对抑郁发作程度、企图自杀和是否为首发患者的亚组分析，并未发现DHH基因的rs7296288 SNP位点与抑郁症临床特征之间有关联，即DHH基因rs7296288 SNP与抑郁症并无显著相关性。结论 DHH基因rs7296288多态性与抑郁症的发病无相关性。

Abstract

Objective To explore the correlation between the rs7296288 single nucleotide polymorphism(SNP) of the DHH gene and the onset of depression. Methods From March 2018 to December 2019, 480 patients with depression in Sichuan Provincial People’s Hospital,Jining Mental Hospital,Yunnan Mental Health Center were collected as the case group, and 329 patients without depression were collected as the control group. Peripheral blood samples were collected and DNA was extracted. After multiple amplification and highthroughput sequencing, statistical software was used to analyze the relevant data. Results The rs7296288 polymorphism of the DHH gene，the AA genotype was 32.9% in the control group and 36.7% in the case group, with no statistical difference; the AC genotype was 52.8% in the control group and 47.7% in the case group, with no statistical difference; the CC genotype was 14.3% in the control group and 15.6% in the case group, with no statistical difference. The co-dominant, dominant, and recessive statistical models were not statistically significant. Subgroup analysis of the degree of depressive episodes, suicide attempts, and first-episode patients did not find an association between the rs7296288 SNP locus of the DHH gene and the clinical features of depression, that is, the SNP rs7296288 of the DHH gene had no significant correlation with depression. Conclusion The rs7296288 polymorphism of DHH gene is not correlated with the pathogenesis of depression.

导出引用

陈婧婕王艺羲梁鹏李悦李健梁芸丹. DHH基因单核苷酸多态性与抑郁症的相关分析[J]. 解剖学报. 2025, 56(2): 158-162 https://doi.org/10.16098/j.issn.0529-1356.2025.02.005

CHEN Jing-jie WANG Yi-xi LIANG Peng LI Yue1 LI Jian LIANG Yun-dan. Association analysis of DHH gene single nucleotide polymorphism and depression[J]. Acta Anatomica Sinica. 2025, 56(2): 158-162 https://doi.org/10.16098/j.issn.0529-1356.2025.02.005

中图分类号： R749.92

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