Objective To explore the relationship of the epilepsy induced by interleukin2(IL-2) and the Janus kinase(Jak)/ signal transducers and activators of transcription(Stats）signal transduction pathway. Methods Immunocytochemistry was applied to study the expression changes of tyrosine kinase Jak1 in brain after IL-2 administration to induce epilepsy, and the changes of N-methyl-D-aspartate receptor-1(NMDAR-1) and glutamic acid(Glu) when preusing Jak1 inhibitor and glucocorticoid prior to IL-2 Results After injecting IL-2 into the lateral ventricle, the rats displayed obvious seizures and the expression of Jak1 was significantly stronger comparing with the control group(P<0.01), immunosuppressants such as cyclosporin A(CsA) could partly inhibit this effect. Jak1 inhibitor genistein and immunosuppressant glucocorticoid could restrain the epilepsy behaviors, and the NMDAR-1 and Glu expressions significantly decreased conferring to the IL-2 group（P<0.05）. Conclusion Jak1 plays an important role in signal tr