INFLUENCE OF QUERCETIN AND BORNYL ACETATE ON CD4SUP>+ /SUP>/CD8SUP>+/SUP>T LYMPHOCYTES IN THE UTERUS FOLLOWING LPSINDUCED ABORTION IN PREGNANT MICE

Acta Anatomica Sinica ›› 2008, Vol. 39 ›› Issue (5) : 734-737.

Welcome to visit Acta Anatomica Sinica! Today is Chinese
Acta Anatomica Sinica ›› 2008, Vol. 39 ›› Issue (5) : 734-737.
论著

INFLUENCE OF QUERCETIN AND BORNYL ACETATE ON CD4SUP>+ /SUP>/CD8SUP>+/SUP>T LYMPHOCYTES IN THE UTERUS FOLLOWING LPSINDUCED ABORTION IN PREGNANT MICE

Author information +
History +

Abstract

Objective To investigate the significance of CD4SUP>+ /SUP>and CD8SUP>+/SUP> T lymphocytes in the uterus in early embryo loss (or resorption), and to elucidate the anti-bortive effect and the immunological modulation of the maternalfetal interaction with quercetin and bornyl acetate. Methods Lipopolysaccharide (LPS)(0.10μg/mouse)was injected via the tail vein in order to induce abortion in 7-day-gestation mice which also received quercetin and bornyl acetate at days 4-7 of gestation. Uterine CD4SUP>+/SUP> and CD8SUP>+/SUP> T lymphocytes of each group (EM>n/EM>=10) were detected by immunohistochemistry. Results The amount of CD4EM>SUP>+ /SUP>/EM>T lymphocytes in the uterus of LPSinduced abortion mice was much higher (EM>P/EM><0.01) than that of the control mice, but there was no significant difference in the amount of CD4SUP>+ /SUP>T lymphocytes (EM>P/EM>>0.05). Also, the rate of CD4SUP>+/SUP> /CD8SUP>+/SUP> was increased significantly (P<0.01). When quercetin and bornyl acetate was used to prevent LPSinduced abortion, fewer CD4SUP>+/SUP> T cells were counted. The effect of quercetin combined with bornyl on antiLPSinduced abortion was more significant, and the rate of CD4SUP>+ /SUP>/

Key words

Embryo resorption / CD4SUP>+/SUP>/CD8SUP>+/SUP> T lymphocyte / Lipopolysaccharide / Immunohistochemistry / Mouse

Cite this article

Download Citations
INFLUENCE OF QUERCETIN AND BORNYL ACETATE ON CD4SUP>+ /SUP>/CD8SUP>+/SUP>T LYMPHOCYTES IN THE UTERUS FOLLOWING LPSINDUCED ABORTION IN PREGNANT MICE[J]. Acta Anatomica Sinica. 2008, 39(5): 734-737

Accesses

Citation

Detail

Sections
Recommended

/