Objective To study the change of the contents of albumin (ALB) in blood serum and liver tissue after human embryohepatic stem cells transplanted into hepatocirrhosis rats induced by CCl-4. Methods Healthy mature male Wistar rats was randomly divided into control group and hepatocirrhosis group. The control group was injected oily solution with 012ml/100g rat weight, the hepatocirrhosis group was subcutaneously injected 60% carbon tetrachloride oily solution with 0.3ml/100g rat weight.Six weeks after injection, hepatocirrhosis group was subdivided into hepatic stem cells sham group and hepatic stem cells transplanted group. The control group and hepatic stem cells sham group was injected culture media, and hepatic stem cells transplanted group was injected human embryohepatic stem cells 2×106 for each rat. On the first day of 11th weeks, all rats were killed. Blood samples were collected from right ventricles and the contents of ALB in serum of each sample was measured. Observed the expression of human EGFR by immunohistochemistry stain. The expressions of ALB in liver tissue was detected by immunofluorescence and Westernblotting. Results In the control and hepatic stem cells sham group, there was no expression of human epidermal growth factor receptor(EGFR), but in hepatic stem cells transplanted group, there were lots of human EGFR positive cells. In hepatic stem cells transplanted group, but in liver tissue and blood serum the contents of ALB were more than that of hepatic stem cells sham group, but similar to the control group. Conclusion In carbon tetrachloride induced hepatocirrhosis rats, transplanted hepatic stem cells could survive long, and coul