Objective To study whether ConA could induce microvascular endothelial cells to secrete IFN-γ. Methods IFN-γ was tested by double antibody sandwich ELISA. Results The microvascular endothelial cells of the intestinal mucous could be remarkably activated by ConA to secret IFN-γ, and the activations of 5\^0mg/L ConA was time_dependent,but the 10\^0 mg/L ConA was not so;There was not obviously different between the group of 5\^0mg/L ConA and that of 10.0 mg/L ConA . Conclusion ConA could induce microvascular endothelial cells of the rat intestinal m