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Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-4 in human papillary thyroid carcinoma and their significances
LI Qian LI Li GUO Shu-qin* ZHANG Yun-liang KONG Fan-qiang LI Fei KANG Jun-peng WU Jing-fang GAO Fu-lu
Acta Anatomica Sinica ›› 2014, Vol. 45 ›› Issue (5) : 675-681.
Expression of fibroblast growth factor-2 and fibroblast growth factor receptor-4 in human papillary thyroid carcinoma and their significances
Objective To investigate the expression of fibroblast growth factor-2 (FGF-2) and fibroblast growth factor receptor-4(FGFR-4) in the papillary thyroid carcinomas（PTC）and clinical significance. Methods Immunohistochemistry and Western blotting for the expression of FGF-2 and FGFR-4 were performed in 89 cases of PTC and 30 cases of normal thyroid tissues (NTT) adjacent to the tumors. Results Immunohistochemistry results showed that, FGF-2 and FGFR-4 expressions were high in thyroid carcinoma (P<0.01，P<0.01)in contrast to that in the normal thyroid tissues, and the difference was statistically significant;There was a positive linear correlation between expressions of FGF-2 and FGFR-4 and lymph node metastasis (χ2=14.798,P<0.01;χ2=7.27,P<0.01)and differentiation degree (χ2=13.824,P<0.01;χ2=16.921, P<0.01) in papillary thyroid carcinoma,while there was no difference in gender,age and tumor size(P>0.05). Analyzed by Western blotting technique,FGF-2 and FGFR-4 expressions in thyroid carcinoma were significantly higher than that in normal tissue,with decrease of cancer degree of tissue differentiation and significantly up regulated expression (P< 0.05). Expressions of FGF-2 and FGFR-4 were in a positive linear correlation in the disease（rs=0.434,P<0.01）. Conclusion The expressions of FGF-2 and FGFR-4 are correlated with papillary thyroid cancer and they participated in the process of invasion and metastasis, both of which have a positive synergistic effect. The degree of malignancy and biological behavior are meaningful and comprehensive indicators,which provide a theoretical basis for the subsequent experimental studies of cellular and molecular biology.
Fibroblast growth factor-2 / Fibroblast growth factor receptor-4 / Invasion / Metastasis / Papillary thyroid carcinoma / Western blotting / Human
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