Welcome to visit Acta Anatomica Sinica! Today is
Chinese
Distribution of monoaminergic neurons in the central nervous system of adult tree shrew
LAN Wei DING Yu-qiang*
Acta Anatomica Sinica ›› 2014, Vol. 45 ›› Issue (1) : 41-46.
Distribution of monoaminergic neurons in the central nervous system of adult tree shrew
Objective To explore the distribution of tyrosine hydroxylase (TH) and tryptophan hydroxylase 2 (Tph2) in the CNS of the adult tree shrew (Tupaia belangeri chinensis). Methods TH and Tph2 expressions in the adult tree shrew were localized using immunohistochemistry. Results TH-immunoreactive signals were mainly distributed in the glomerular layer of the olfactory bulb, striatum, paraventricular hypothalamic nucleus, subtantia nigra, ventral tegmental area and locus coeruleus. Tph2- immunoreactive signals were mainly located in the midbrain and the pontine raphe complex. Conclusion The distribution pattern of TH and Tph2 in the tree shrew CNS is consistent with that of most vertebrate. Some distribution characteristics shown in the tree shrew support its close afnity to primates. The distribution pattern of TH and Tph2 in the tree shrew CNS indicates the conservation of the evolution of the dopamine and serotonin systems, and suggests that the tree shrew can be a potential animal model to study human mental diseases associated with the dopamine and serotonin systems.
Tyrosine hydroxylase / Tryptophan hydroxylase 2 / Distribution / Immunohistochemistry / Tree shrew
［1］Bjorklund A, Dunnett SB. Dopamine neuron systems in the brain: an update ［J］. Trends Neurosci, 2007, 30(5): 194-202.
［2］Guo Ch, Ding YQ. Genetic pathways controlling the development of dompaminergic and serotonergic neurons［J］. Chinese Journal of Nature, 2009, 31(3): 142-147, 152. (in Chinese)
郭超，丁玉强. 多巴胺和5羟色胺神经元发育的基因调控途径［J］. 自然杂志，2009, 31(3): 142147-152.
［3］Janecka JE, Miller W, Pringle TH, et al. Molecular and genomic data identify the closest living relative of primates ［J］. Science, 2007, 318(5851): 792-794.
［4］Tigges J, Shantha TR. A Stereotaxic Brain Atlas of Tree Shrew (Tupaia Glis)［M］. New York: The Williams & Wilkins Company, 1969.
［5］Dahlstroem A, Fuxe K. Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons［J］. Acta Physiol Scand Suppl, 1964, 232:1-55.
［6］Hokfelt T, Martensson R, Bjorklund A, et al. Classical Transmit-ters in The CNS. Part I. Handbook of Chemical Neuroanatomy. Vol. 2［M］. Amsterdam: Elsevier, 1984：277-386.［7］Smeets WJ, Gonzalez A. Catecholamine systems in the brain of vertebrates: new perspectives through a comparative approach ［J］. Brain Res Brain Res Rev, 2000, 33(2-3): 308-379.
［8］Takeuchi Y, Kimura H, Sano Y. Immunohistochemical demonstra-tion of the distribution of serotonin neurons in the brainstem of the rat and cat［J］. Cell Tissue Res, 1982, 224(2): 247-267.
［9］Hale MW, Lowry CA. Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits ［J］. Psychopharmacology (Berl), 2011, 213(2-3): 243-264.
［10］Rice MW, Roberts RC, Melendez-Ferro M, et al. Neurochemical characterization of the tree shrew dorsal striatum［J］. Front Neuroanat, 2011, 5: 53.
［11］Arsenault MY, Parent A, Seguela P, et al. Distribution and morphological characteristics of dopamine-immunoreactive neurons in the midbrain of the squirrel monkey (Saimiri sciureus) ［J］. J Comp Neurol, 1988, 267(4): 489-506.
［12］Wang J, Zhou QX, Lv LB, et al. A depression model of social defeat etiology using tree shrews ［J］. Zoological Research, 2012, 33(1): 92-98.（in Chinese）
王静，周启心，吕龙宝，等. 社会竞争失败病因学的抑郁症树鼩模型［J］. 动物学研究, 2012, 33(1): 92-98.
［13］Fan Y, Huang ZY, Cao CC, et al. Genome of the Chinese tree shrew ［J］. Nat Commun, 2013, 4: 1426.
/
| 〈 |
|
〉 |
