Abnormal expression of AMPA receptor in hippocampus of senescence accelerated mouse prone 8 correlated to synaptic plasticity

FENG Min ZHANG Ying-jun LU Juan XIONG Yin-yi WU Qiao-feng YU Mei-ling LU Sheng-feng YU Shu-guang*

Acta Anatomica Sinica ›› 2014, Vol. 45 ›› Issue (1) : 15-19.

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Acta Anatomica Sinica ›› 2014, Vol. 45 ›› Issue (1) : 15-19. DOI: 10.3969/j.issn.0529-1356.2014.01.003

Abnormal expression of AMPA receptor in hippocampus of senescence accelerated mouse prone 8 correlated to synaptic plasticity

  • FENG Min 1,2  ZHANG Ying-jun3  LU Juan2  XIONG Yin-yi2  WU Qiao-feng2  YU Mei-ling4  LU Sheng-feng5  YU Shu-guang 2*
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Abstract

Objective To observe the expression differences of AMPA receptor in hippocampal neurons between SAMP8 and SAMR1 and to explore the pathogenesis of Alzheimer’S disease(AD). Methods Male SAMP8 mice of 10-month old were taken as animal model of AD and SAMR1 mice were taken as control group. Morris water maze(MWM), electron microscope and western blotting were used in this study. Results Comparing with the control group, the model group had significant learning impairment and memory retention deficits. The thickness of post synaptic density(PSD) and the curvature of the synaptic interface in the model group dicrease. The width of synaptic cleft in the model group increased. The expression of GluR2 in the model group dicreased. There were no significant differences in the expression of GluR1 between two groups. Conclusions Impaired synaptic plasticity mediated by pathological alteration of AMPA receptor in hippocampus mey be the pathogenesis underlying learning and memory disorders of AD.

Key words

Senescence accelerated mouse prone 8 / Alzheimer’s disease / α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor / Synaptic plasticity / Learning  / and memory / Morris water maze / Western blotting / Mouse

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FENG Min ZHANG Ying-jun LU Juan XIONG Yin-yi WU Qiao-feng YU Mei-ling LU Sheng-feng YU Shu-guang*. Abnormal expression of AMPA receptor in hippocampus of senescence accelerated mouse prone 8 correlated to synaptic plasticity[J]. Acta Anatomica Sinica. 2014, 45(1): 15-19 https://doi.org/10.3969/j.issn.0529-1356.2014.01.003

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