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Protective effect of astragalus polysaccharides in model rats of doxorubicin induced cardiac injury
GUAN Peng XU Bing-yuan LI Ya-qing GUO Qiu-hong WANG Na*
Acta Anatomica Sinica ›› 2013, Vol. 44 ›› Issue (5) : 685-688.
Protective effect of astragalus polysaccharides in model rats of doxorubicin induced cardiac injury
Objective To determine the protective effect of astragalus polysaccharides (APS) in doxorubicin induced heart faiure（HF）. Methods Thirty male Sprague-Dawly rats were randomly divided into three groups: control group, HF group and APS group. APS group received APS ［3g/(kg〖DK〗·d］for 14 days. HF group and APS group received doxorubicin 10.4mg/kg every 2 days for 4 times. Ventricular remodeling,apoptosis, and antioxidant indices were examined after the last intragastric administration. Results APS protected heart from myocardial fibrosis, myofibrils dissolve and broke, and mitochondria swelling. Evident cardiac damage induced by doxorubicin was revealed by hemodynamic changes and TUNEL staining compared to the control group. APS treatment caused significant attenuation of malonyldialdehyde（MDA）and Bax express. Superoxide dismutase (SOD) activity and Bcl-2 expression were significantly increased by APS in heart failure rats. Conclusion APS decreases doxorubicin-induced cardiotoxicity.
Astragalus polysaccharides / Doxorubicin / Heart failure / Antioxidation / TUNEL staining｜ Rat
［1］Hadi N, Yousif NG, Al-Amran FG, et al. Vitamin E and telmisartan attenuates doxorubicin induced cardiac injury in rat through down regulation of inflammatory response［J］. BMC Cardiovasc Disord, 2012,12(1):63-69.
［2］Li ZhJ, Zhang Y, Liu YM, et al. Effect of astragalus polysaccharin on expression of nephrin and podocin in podocytes of early diabetic nephropathy rats ［J］. Chinese Journal of Pathophysiology, 2011,27(9):1772-1776.(in Chinese)
李志杰，张悦，刘煜敏，等. 黄芪多糖对早期糖尿病肾病大鼠足细胞nephrin和podocin表达的影响［J］.中国病理生理杂志，2011,27(9):1772-1776.
［3］Ma LJ, Tian ZhJ. Effects of acute exercise to exhaustion on Bcl-2, Bax gene of rat, sheart after supplement of astragalus polysaccharide［J］. Journal of Huazhong Normal University (Natural Sciences), 2012,46(2):214-217. (in Chinese)
马兰军，田振军. 黄芪多糖对力竭运动大鼠心肌细胞凋亡及Bcl-2、Bax蛋白表达的影响［J］. 华中师范大学学报（自然科学版），2012,46(2):214-217.
［4］zdogan K, Taskin E, Dursun N. Protective effect of carnosine on adriamycin-induced oxidative heart damage in rats［J］. Anadolu Kardiyol Derg,2011,11(1):3-10
［5］Zhang HZh, Wang LN, Wang ZhY. Protective effect of lutein on adriamycin-induced cardiotoxicity and nephrotoxicity［J］. Modern Medicine Journal of China, 2009,11(8):12-15. (in Chinese)
张慧珠，王丽娜，王智云. 叶黄素对阿霉素所致大鼠心肾损伤的保护作用［J］. 中国现代医药杂志，2009,11(8):12-15.
［6］Mohamed HE, Asker ME, Ali SI, et al. Protection against doxorubicin cardiomyopathy in rats: role of phosphodiesterase inhibitors type 4［J］. J Pharm Pharmacol, 2004,56(6):757-768.
［7］Jin D, Liang Y, Zheng WF, et al. Antioxidant activity of polysaccharides from Scutellaria baicalensis Georgi in vitro ［J］. Journal of Traditional Chinese Veterinary, 2012,31(3):33-37. (in Chinese)
金迪，梁英，郑文凤，等. 黄芩多糖体外抗氧化活性研究［J］. 中兽医医药杂志，2012,31(3):33-37.
［8］Gao X, Li LF, Liu BY. Effect of Astragalus polysaccharides on stress response ability and regulation of free radicals in mice ［J］. China Preventive Medicine, 2010,11(2):120-121. (in Chinese)
高旭，李丽芬，刘斌钰. 黄芪多糖对小鼠应激能力和自由基代谢的影响［J］. 中国预防医学杂志，2010,11(2):120-121.
［9］Liu QL, Song YM, Liu Ch. Neuregulin-1β inhibits cardiomyocyte apoptosis in adriamycin-induced rat card iomyopathy by regulating bcl-2 and bax［J］. Acta Academiae Medicinae Militaris Tertiae, 2009,31(24):2448-2451. (in Chinese)
刘启亮，宋耀明，刘超. Neuregulin1β对阿霉素致心衰大鼠心肌细胞凋亡及bax、bcl-2蛋白表达的干预效应［J］. 第三军医大学学报，2009,31(24):2448-2451.
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