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Clinical significance of nucleolin expression in thyroid papillary carcinoma
Lü Shun-zeng ZHAO Jing TIAN Hua* LI Fei LI Gui-bao FANG Yun-hai HU Yan-lai YIN Qun-sheng
Acta Anatomica Sinica ›› 2013, Vol. 44 ›› Issue (4) : 498-502.
Clinical significance of nucleolin expression in thyroid papillary carcinoma
Objective To explore the expression of nucleolin in thyroid papillary carcinoma, and discuss its clinical significance.Methods Nucleolin, chemokine receptor 7 (CCR7), matrix metalloproteinase 9 (MMP-9) were detected by immunohistochemical technique
(SP) in 60 cases of normal thyroid tissues and 60 cases of thyroid papillary carcinoma tissues. The relationship among the expressions of nucleolin, CCR7, and MMP-9 and gender, age, or tumor size was analyzed. The correlation between nucleolin and
CCR7/MMP-9 was analyzed. Results The expression rate of nucleolin in normal thyroid and thyroid papillary carcinoma tissues was 0, 100% respectively. The expression of nucleolin in thyroid papillary carcinoma with lymph node metastasis was mainly located
in nucleus, cytoplasm and cell membrane while the expression of nucleolin was only located in nucleus in thyroid papillary carcinoma tissues without lymph node metastasis. Differences were statistically significant（P<0.05）. No significant correlation
was found between the expression of nucleolin and gender, age or tumor size (P>0.05). In thyroid papillary carcinoma, the extra nuclear expression of nucleolin was positively correlated with the expression of CCR7 and MMP-9（P<0.01）. Conclusion Our
study suggests that nucleolin can express in thyroid papillary carcinoma and the distribution of nucleolin differs between metastatic carcinoma tissues and nonmetastatic carcinoma. Nucleolin is closely associated with CCR7 and MMP-9. NCL can be
used as an important indicator for cancer metastasis.
Nucleolin / Chemokine receptor 7 / Matrix metalloproteinase 9 / Thyroid papillary carcinoma / Immunohistochemistry / Human
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