Distribution of neuroglobin in different tissues and cells of the adult yak

CAO Liang LIU Xia SHI Ning-ning LI Sheng-jie DU Xiao-hua*

doi:10.3969/j.issn.0529-1356.2013.01.01.013

Acta Anatomica Sinica ›› 2013, Vol. 44 ›› Issue (1) : 68-72. DOI: 10.3969/j.issn.0529-1356.2013.01.01.013

Distribution of neuroglobin in different tissues and cells of the adult yak

CAO Liang¹LIU Xia²SHI Ning-ning²LI Sheng-jie²DU Xiao-hua¹*

Author information +

History +

Abstract

Objective To explore the localization of neuroglobin (NGB) in adult yak tissues and cells. Methods Eight health adult yaks were used in this study. NGB expression in adult yak tissues and cells was localized using the immunohistochemical SP technique. Results NGB-positive cells were mainly distributed in nerve cells, adrenal gland, adenohypophysis and pancreas islet, testis, efferent ductules of testis and epididymal epithelium of genital system. NGB-immunoreactive product was located in the cytoplasm. The NGB-positive cells were found in the fundic glands of abomasum and duodenal glands.Conclusion The high expression of NGB in tissues and cells of nervous system, endocrine system, genital system and alimentary system in yak suggested that NGB might play an important role in the utilization of oxygen and physiological functions.

Key words

Neuroglobin / Distribution / Immunohistochemistry / Yak

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

CAO Liang LIU Xia SHI Ning-ning LI Sheng-jie DU Xiao-hua*. Distribution of neuroglobin in different tissues and cells of the adult yak[J]. Acta Anatomica Sinica. 2013, 44(1): 68-72 https://doi.org/10.3969/j.issn.0529-1356.2013.01.01.013

References

［1］ Burmester T, Weich B, Reinhardt S, et al. A vertebrate globin expressed in the brain ［J］. Nature, 2000, 407(6803): 520-523.

［2］Reuss S, Saaler-Reinhardt S, Weich B, et al. Expression analysis of neuroglobin mRNA in rodent tissues［J］. Neuroscience, 2002, 115(3): 645-656.

［3］ Bai ZhZh, Han ShF, Yang YZh, et al. Genetic cloning and expression of neuroglobin in high altitude hypoxic adaptation species-plateau pika(Ochotona curzoniae)［J］. Acta Theriologica Sinica, 2010, 30(1): 74-78.（in Chinese）

白振忠, 韩淑芬, 杨英忠等. 高原鼠兔脑红蛋白基因的克隆与组织表达［J］. 兽类学报, 2010, 30(1): 74-78.

［4］Zivin JA. Factors determining the therapeutic window for stroke ［J］. Neurology, 1998, 50(3): 599-603.

［5］Greenberg DA, Jin KN, Khan AA. Neuroglobin: an endogenous neuroprotectant［J］. Curr Opin Pharmacol, 2008, 8(1): 20-24.

［6］Sun Y, Jin K, Mao XO, et al. Neuroglobin is up-regulated by and protects neurons from hypoxic-ischemic-injury［J］. Proc Natl Acad Sci USA, 2001, 98(26): 15306-15311.［7］ Shang AJ, Zhou DB, Zhang ChG, et al.Cellular localization of neuroglobin expression in rat brain［J］. Chinese Journal of Neuromedicine, 2006, 5(9): 891-893.（in Chinese）

尚爱加, 周定标, 张成岗,等. 脑红蛋白在大鼠脑内表达的细胞定位［J］. 中华神经医学杂志, 2006, 5(9): 891-893. 

［8］Laufs T, Wystub S, Reuss S, et al. Neuron-specific expression of neuroglobin in mammals［J］. Neurosci Lett, 2004, 362(2): 83-86.

［9］Chen XQ, Qin LY, Zhang CG, et al. Presence of neuroglobin in cultured astrocytes［J］. Glia, 2005, 50(2): 182-186.

［10］Avivi A, Gerlach F, Joel A. Neroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat spalax［J］. Proc Natl Acad Sci USA, 2010, 107(50): 21570-21575.

［11］ Shang AJ, Zhou DB, Meng XH, et al. Distribution of neuroglobin in spinal code of adult rat［J］. Acta Anatomica Sinica, 2006, 37(5): 492-494.（in Chinese）

尚爱加, 周定标, 孟祥辉, 等. 脑红蛋白在成年大鼠脊髓中的分布［J］. 解剖学报, 2006, 37(5): 492-494.

［12］ Qin HJ, Zhang LSh, Guan P, et al. Study on the distribution and location of neuroglobin in human tissues and cells［J］. Journal of Sichuan University(Medical Science Edition), 2008, 39(4): 609-611.（in Chinese）

秦豪杰, 张录顺, 官鹏, 等. 脑红蛋白在人体组织细胞的定位分布及意义［J］. 四川大学学报(医学版), 2008, 39(4): 609-611.

［13］Schmidt M, Giessl A, Laufs T, et al. How does the eye breathe? Evidence for neuroglobin-mediated oxygen supply in the mammalian retina［J］. J Biol Chem, 2003, 278(3): 1932-1935.

［14］ Liao WG, Gao YQ, Cai MCh, et al. Effect of hypoxia on secretion of testosterone and expression of its synthesis relative protein and enzymes in rats［J］. Chinese Journal of Aerospace Medicine, 2006, 17(3): 191-195.（in Chinese）

廖卫公, 高钰琪, 蔡明春, 等. 低氧对雄性大鼠睾酮分泌及其合成相关蛋白和酶表达的影响［J］. 中华航空航天医学杂志, 2006, 17(3): 191-195. 