Objective To study correlations among scan parameter, image quality and radiation dose of cadaver wrist multislice spiral computed tomography(MSCT). Methods Four cadaver wrists labeled as 1-4 respectively underwent 16-slice CT (Siemens Somatom Sensation16) scan. Totally 11 groups of MSCT scan were performed for each specimen.Scan parameters were different. An additional scan was performed for the third specimen with a high voltage(140kV) and a high current(300mAs).Thin-slice coronal images were reformatted for all the scans.Each reformatted coronal image was evaluated. Correlations among scan parameter, image quality and radiation dose were analyzed. Results Image quality of each wrist with different scan parameters did not show evident difference. Radiation dose increased linearly with current and increased curvedly with voltage. Radiation dose did not change obviously when pitch was changed. Conclusion Relations are different between radiation dose and different scan parameters. Correlations among scan parameter, image quality and radiation dose are instructive in practice.