Objective To investigate associativity and mechanism of β-catenin with ovarian cancer metastasis. Methods The different expressions of β-catenin in high and low metastatic human ovarian serous cystadenocarcinoma cells（HO-8910PM and HO-8910） were detected by immunofluorescence staining, Western blotting and RT-PCR analysis. To further investigate the regulated mechanism of β-catenin with ovarian cancer metastasis, low metastatic human ovarian serous cystadenocarcinoma HO-8910 cells were treated by hepatocyte growth factor(HGF). The expression change of β-catenin in HO-8910 cells was investigated by the same technology mentioned above. Then, HO-8910 cells invasion and migration abilities were assessed by Transwell chambers and scratch wound migration assay. Results The expression of β-catenin was significantly lower in HO-8910PM cells than that in HO-8910 cells (P<0.05). HGF could downregulate the expression of β-catenin in HO-8910 cells (P<0.05) and enhance cell invasion (P<0.05) and migration. Conclusion The lower expression of β-catenin may be correlated with invasion and migration pot