Objective To explore the relationship between implantation and the receptors for erythrina cristagalli lectin (ECL) and dolichos biflorus agglutinin (DBA) distributed in mouse endometrium. Methods During early pregnancy, ECL and DBA marked by biotin were used to observe the distribution and change in 2 kinds of lectin receptors in pregnant and nonfertile mouse endometrium. Results On the pregnant side, the ECL receptor is mainly distributed in the trophoblast and its basement membrane, the surface of the decidual cells and their surrounding extracellular matrix(ECM). On the nonfertile side, the lectin receptor is mainly expressed on the superficial surface of the endometrial epithelium and uterine gland epithelium. On the pregnant side, the DBA receptor is mainly expressed in the trophoblast and its basement membrane and the basement membrane of blood vessels. However, on the nonfertile side, the DBA receptor is mainly in the basement membarane of blood vessels.Conclusion The receptors for ECL and DBA play a key roles during blastocyst implantation in mice.