Analysis of cerebral amyloid angiopathy samples from Human Brain Bank of Hebei Medical University

CUI  Zu-qi1  YE  Meng-yao2  ZHOU  Yi1  MI  Shi-xiong3  YANG  Qian3  MA  Min3  WANG  Ming2 WANG  Shi-yi1  YU  Qi-han1  CUI  Hui-xian3  DU  Juan3*

doi:10.16098/j.issn.0529-1356.2025.06.010

PDF(2586 KB)

Acta Anatomica Sinica ›› 2025, Vol. 56 ›› Issue (6) : 704-712. DOI: 10.16098/j.issn.0529-1356.2025.06.010

Anatomy

Analysis of cerebral amyloid angiopathy samples from Human Brain Bank of Hebei Medical University

CUI Zu-qi¹ YE Meng-yao² ZHOU Yi¹ MI Shi-xiong³ YANG Qian³ MA Min³ WANG Ming² WANG Shi-yi¹ YU Qi-han¹ CUI Hui-xian³ DU Juan^3*

Author information +

History +

Abstract

Objective To analyze the basic conditions and pathological characteristics of the samples in the Human Brain Bank of Hebei Medical University, which were pathologically diagnosed as cerebral amyloid angiopathy, and to provide reference for the research of related diseases. Methods The basic data of gender, age, apolipoprotein E genotype, pathological classification of cerebral amyloid angiopathy, Alzheimer’s disease-related pathological change score, comorbidities and other pathological information were analyzed. Results Up to October 2024, twenty samples were confirmed by pathological diagnosis, with a male to female ratio of 3∶1 and an average age of (80.90 ± 8.08) years. Involve three kinds of apolipoprotein E subtype, 5 kinds of genotypes (ε2/ε3、ε2/ε4、ε3/ε3、ε3/ε4、ε4/ε4); There were 2 pathologic types, including 6 cases of type 1 and 14 cases of type 2. The pathological grade included 3 grades. The severity grade and subtype classification of cerebral amyloid vascular disease were correlated with the degree of pathological changes of Alzheimer’s disease. Cerebral amyloid angiopathy samples could coexist with other degenerative diseases with high comorbidity. Conclusion The incidence of cerebral amyloid angiopathy is higher in the aged samples collected based on Brain Bank, which coexists with conditions such as Alzheimer’s disease and microbleeds, etc. It provides more detailed pathological diagnosis basis for further scientific research sharing of samples.

Key words

Human Brain Bank

/ Human brain sample / Cerebral amyloid angiopathy / Alzheimer’s disease / Comorbidity / Neuropathological diagnosis / Human

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

CUI Zu-qi YE Meng-yao ZHOU Yi MI Shi-xiong YANG Qian MA Min WANG Ming WANG Shi-yi YU Qi-han CUI Hui-xian DU Juan. Analysis of cerebral amyloid angiopathy samples from Human Brain Bank of Hebei Medical University[J]. Acta Anatomica Sinica. 2025, 56(6): 704-712 https://doi.org/10.16098/j.issn.0529-1356.2025.06.010

References

［1］ Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, et al. Cerebral amyloid angiopathy and Alzheimer disease-one peptide, two pathways ［J］. Nat Rev Neurol, 2020, 16(1):30-42.

［2］ Love S, Chalmers K, Ince P, et al. Development, appraisal, validation and implementation of a consensus protocol for the assessment of cerebral amyloid angiopathy in post-mortem brain tissue ［J］. Am J Neurodegener Dis, 2014, 3(1):19-32.

［3］ Arvanitakis Z, Leurgans SE, Wang Z, et al. Cerebral amyloid angiopathy pathology and cognitive domains in older persons ［J］. Ann Neurol, 2011, 69(2): 320-327.

［4］ Yamada M. Cerebral amyloid angiopathy: emerging concepts ［J］. J Stroke, 2015, 17(1): 17-30.

［5］ Biffi A, Greenberg SM. Cerebral amyloid angiopathy: a systematic review ［J］. J Clin Neurol, 2011, 7(1):1-9.

［6］ Wang X, Chen Zh, Wu JL, et al. Standardized operational protocol for the China Human Brain Bank Consortium (2nd edition) ［J］. Acta Anatomica Sinica, 2024, 55(6)：734-745. (in Chinese)

王雪，陈震，吴娟利，等. 中国人脑组织库协作联盟标准化操作方案第2版［J］. 解剖学报，2024，55(6)：734-745.

［7］ Du J, Mi ShX, Jin YCh, et al. Analysis of Human Brain Bank samples from Hebei Medical University［J］. Acta Anatomica Sinica, 2024, 55(4)：437-444. (in Chinese)

杜鹃，米世雄，靳玉川，等. 河北医科大学人脑组织库样本分析［J］. 解剖学报，2024, 55(4)：437-444.

［8］ Thal DR, Griffin WST, de Vos RAI, et al. Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease ［J］. Acta Neuropathol, 2008, 115(6):599-609.

［9］ Montine TJ, Phelps CH, Beach TG, et al. National institute on aging-Alzheimer’s association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach［J］.Acta Neuropathol, 2012, 123(1):1-11.

［10］ Kovacs GG, Ferrer I, Grinberg LT, et al. Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy ［J］. Acta Neuropathol, 2016, 131(1): 87-102.

［11］ Ferrer I, Santpere G, Leeuwen FW. Argyrophilic grain disease ［J］. Brain, 2008, 131(6):1416-1432.

［12］ Nelson PT, Dickson DW, Trojanowski JQ, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report ［J］. Brain, 2019,142(6): 1503-1527.

［13］ Nelson, PT, Lee EB, Cykowski MD, et al. LATE-NC staging in routine neuropathologic diagnosis: an update ［J］. Acta Neuropathol, 2023,145(2):159-173.

［14］ Koga S, Dickson DW. Recent advances in neuropathology, biomarkers and therapeutic approach of multiple system atrophy ［J］. J Neurol Neurosurg Psychiatry, 2018, 89(2):175-184.

［15］ Attems J, Lauda F, Jellinger KA. Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy: an autopsy study ［J］. J Neurol, 2008, 255(1): 70-88.

［16］ Greenberg SM, Vonsattel JPG, Stales JW, et al.The clinical spectrum of cerebral amyloid angiopathy：presentations without lobar hemorrhage ［J］.Neurology, 1993, 43(10): 2073-2079.

［17］ Huang P, Ren RJ, Pan Y, et al. Early-onset Alzheimer’s disease complicated with cerebral amyloid angiopathy: a case report［J］. Journal of Diagnostics Concepts and Practice, 2022, 21(1): 86-89. (in Chinese)

黄沛，任汝静，潘煜，等. 早发型阿尔茨海默病合并脑淀粉样血管病一例报道［J］. 诊断学理论与实践，2022，21(1): 86-89.

［18］ Pfeifer LA, White LR, Ross GW, et al. Cerebral amyloid angiopathy and cognitive function: the HAAS autopsy study ［J］. Neurology, 2002, 58(11): 1629-1634.

［19］ Thal DR, Ghebremedhin E, Orantes M, et al. Vascular pathology in Alzheimer’s disease: correlation of cerebral amyloid angiopathy and arteriosclerosis/lipohyalinosis with cognitive decline ［J］. J Neuropathol Exp Neurol, 2003, 62(12):1287-1301.

［20］ Thal DR, Capetillo-Zarate E, Larionov S, et al. Cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood Xow disturbances ［J］. Neurobiol Aging, 2008, 30(12):1936-1948.

［21］ Greenberg SM, Rebeck GW, Vonsattel JP, et al. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy ［J］. Ann Neurol, 1995, 38(2): 254-259.

［22］ O’Donnell HC, Rosand J, Knudsen KA, et al. Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage ［J］. New Engl J Med, 2000, 342(4): 240-245.

［23］ Richard E, Carrano A, Hoozemans J, et al. Characteristics of dyshoric capillary cerebral amyloid angiopathy ［J］. J Neuropathol Exp Neurol, 2010, 69(11):1158-1167.

［24］ Sharma R, Dearaugo S, Infeld B, et al. Cerebral amyloid angiopathy: review of clinicoradiological features and mimis ［J］. J Med Imaging Radiat Oncol, 2018, 62:451-463.

［25］ Itoh Y, Yamada M, Suematsu N, et al. Influence of apolipoprotein E genotype on cerebral amyloid angiopathy in the elderly ［J］. Stroke, 1996, 27(2): 216-218.

［26］ Yamada M, Itoh Y, Otomo E, et al. Lack of the association between apolipoprotein E and cerebral amyloid angiopathy in the elderly Japanese ［J］. Ann Neurol, 1996, 39(5): 683-684.

［27］ Bales KR, Liu F, Wu S, et al. Human APOE isoform-dependent effects on brain beta-amyloid levels in PD APP transgenic mice ［J］. J Neurosci, 2009, 29(21): 6771-6779.

［28］ Thal DR, Larionov S, Abramowski D, et al. Occurrence and colocalization of amyloid beta-protein and apolipoprotein E in perivascular drainage channels of wild-type and APP-transgenic mice ［J］. Neurobiol Aging, 2007, 28(8): 1221-1230.

［29］ Wang XX, Zhu KQ, Wu W, et al. Prevalence of mixed neuropathologies in age-related neurodegenerative diseases: a community-based autopsy study in China ［J］. Alzheimers Dement, 2025, 21(1):e14369.

［30］ Wu W, Wang Xue, Xu YY, et al. Neuropathological comorbidity, genetics and cognition in a Chinese community-based autopsy cohort ［J］. Brain, 2025, 148(7): 2481-2492.

［31］ Xiong L, Boulouis G, Charidimou A, et al. Dementia incidence and predictors in cerebral amyloid angiopathy patients without intracerebral hemorrhage ［J］. J Cereb Blood Flow Metab, 2018, 38 (2): 241-249.

［32］ Wilson D, Charidimou A, Ambler G, et al. Recurrent stroke risk and cerebral microbleed burden in ischemic stroke and TIA: a meta-analysis ［J］. Neurology, 2016, 87(14):1501-1510.

［33］ Ma Ch, Qiu WY, Qian XJ, et al. The construction of the Chinese Human Brain Bank: promoting the in-depth development of brain science research ［J］. Acta Anatomica Sinica, 2024, 55(6)：655-656. (in Chinese)

马超，仇文颖，钱晓菁，等. 中国人脑组织库的建设：推动脑科学研究向纵深发展［J］. 解剖学报，2024, 55(6): 655-656.