Fractional anisotrophy analysis and visualization on the reverse computing of RGB components as diffusion tensor in substantia nigra

doi:10.16098/j.issn.0529-1356.2025.04.011

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Acta Anatomica Sinica ›› 2025, Vol. 56 ›› Issue (4) : 459-465. DOI: 10.16098/j.issn.0529-1356.2025.04.011

Anatomy

Fractional anisotrophy analysis and visualization on the reverse computing of RGB components as diffusion tensor in substantia nigra

LIU Yu-qing^1,2 WANG Xiao-jun³ JI Da-feng⁴ SUN Hai-hua⁵ XU Xiao-lu⁵ ZHANG Xin-hua^1*

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Abstract

Objective To explore the application value of fractional anisotropy (FA) analysis of RGB component transformation in different directions of fibers in substantia nigra in Parkinson’s disease (PD). Methods There were 35 cases of PD and 37 cases of normal control group. After being performed by brain diffusion tensor imaging (DTI) scanning, the sequence was imported into 3DSlicense 5. 6. 0, and the diffusion module was used to implement pseudo color mapping based on FA, locate and segment substantia nigra, and use the substantia nigra mask as the tracking starting point. After forming tracing, fibers were imported into DTIANALYSIS 1.51, converting the RGB components into FA values for analysis, and visualized the analysis result . At the same time, fiber length, fiber density, and segmented FA point cloud percentage were compared. Results Compared with the normal group, the length of substantia nigra fibers in the PD group was shorter［(95.14±19.85) mm vs (115.99± 21.39) mm,P<0.01］, and there was a statistical difference between the two groups. There was no statistical difference in fiber density［(0.07 ± 0.05)/mm3 vs (0.10 ± 0.12)/mm3, P >0.05］ between control group and PD group. The percentage of FA segment point clouds in the PD group was lower than that in the normal group at 0. 9-1, but the principal component characteristics of the point cloud ratios in each FA segment were not significant. Conclusion Based on the transformation of RGB components into FA analysis, the length, density, and FA values of substantia nigra nerve fibers in PD patients can be quantified and visualized, providing a basis for the study of PD neural pathways.

Key words

Parkinson’s disease / Substantia nigra / Fiber / Diffusion tensor imaging / Visualization / Human

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LIU Yu-qing WANG Xiao-jun JI Da-feng SUN Hai-hua XU Xiao-lu ZHANG Xin-hua. Fractional anisotrophy analysis and visualization on the reverse computing of RGB components as diffusion tensor in substantia nigra[J]. Acta Anatomica Sinica. 2025, 56(4): 459-465 https://doi.org/10.16098/j.issn.0529-1356.2025.04.011

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