Molecular mechanism and therapeutic strategies of necrotic apoptosis in Alzheimer's disease

doi:10.16098/j.issn.0529-1356.2025.02.015

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Acta Anatomica Sinica ›› 2025, Vol. 56 ›› Issue (2) : 239-247. DOI: 10.16098/j.issn.0529-1356.2025.02.015

Review

Molecular mechanism and therapeutic strategies of necrotic apoptosis in Alzheimer's disease

LU Zhi-cheng^1,2 TANG Li-na ^1,2 MO Sheng-long ^1,2 YANG Cheng-min² JIAN Chong-dong² SHANG Jing-wei ^2*
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Abstract

This review delves into the pivotal role of necrotic apoptosis in Alzheimer’s disease (AD), with a focus on treatment strategies, drug development, prospects, and challenges, highlighting its significance in the progression of the disease. Firstly, necrotic apoptosis plays a crucial role in the pathogenesis of AD, particularly in association with the abnormal metabolism of β-amyloid (Aβ) and Tau proteins. The primary focus of drug design is to regulate the metabolism pathways of these two proteins to slow down or inhibit the progression of necrotic apoptosis. Secondly, the progress in drug development further emphasizes the importance of necrotic apoptosis in treating AD. Current research mainly focuses on drugs that affect the metabolism of Aβ and Tau proteins, such as lecanemab. Still, inconsistent result underscore the necessity for a more comprehensive understanding of the molecular mechanisms of necrotic apoptosis. Finally, the prospects and challenges of necrotic apoptosis research in AD are thoroughly discussed. A deeper understanding of necrotic apoptosis contributes to a better comprehension of the pathological mechanisms of AD but also may reveal new therapeutic targets. However, challenges such as multifactorial influences and the selection of treatment timing necessitate further in-depth research in the future. In conclusion, this review advocates for future research to deepen the understanding of the molecular mechanisms of necrotic apoptosis, enhance research on treatment strategies, gain a deeper understanding of its cross-regulation with other cell death pathways, and promote collaboration between basic research and clinical practice to advance the comprehensive understanding and treatment of Alzheimer’s disease and necrotic apoptosis.

Key words

Alzheimer’s disease / Necrotic apoptosis / β-amyloid protein / Tau protein

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LU Zhi-cheng TANG Li-na MO Sheng-long YANG Cheng-min JIAN Chong-dong SHANG Jing-wei. Molecular mechanism and therapeutic strategies of necrotic apoptosis in Alzheimer's disease[J]. Acta Anatomica Sinica. 2025, 56(2): 239-247 https://doi.org/10.16098/j.issn.0529-1356.2025.02.015

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