Association analysis of DHH gene single nucleotide polymorphism and depression

doi:10.16098/j.issn.0529-1356.2025.02.005

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Acta Anatomica Sinica ›› 2025, Vol. 56 ›› Issue (2) : 158-162. DOI: 10.16098/j.issn.0529-1356.2025.02.005

Association analysis of DHH gene single nucleotide polymorphism and depression

CHEN Jing-jie¹ WANG Yi-xi² LIANG Peng¹ LI Yue¹ LI Jian^1* LIANG Yun-dan^1*

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Abstract

Objective To explore the correlation between the rs7296288 single nucleotide polymorphism(SNP) of the DHH gene and the onset of depression. Methods From March 2018 to December 2019, 480 patients with depression in Sichuan Provincial People’s Hospital,Jining Mental Hospital,Yunnan Mental Health Center were collected as the case group, and 329 patients without depression were collected as the control group. Peripheral blood samples were collected and DNA was extracted. After multiple amplification and highthroughput sequencing, statistical software was used to analyze the relevant data. Results The rs7296288 polymorphism of the DHH gene，the AA genotype was 32.9% in the control group and 36.7% in the case group, with no statistical difference; the AC genotype was 52.8% in the control group and 47.7% in the case group, with no statistical difference; the CC genotype was 14.3% in the control group and 15.6% in the case group, with no statistical difference. The co-dominant, dominant, and recessive statistical models were not statistically significant. Subgroup analysis of the degree of depressive episodes, suicide attempts, and first-episode patients did not find an association between the rs7296288 SNP locus of the DHH gene and the clinical features of depression, that is, the SNP rs7296288 of the DHH gene had no significant correlation with depression. Conclusion The rs7296288 polymorphism of DHH gene is not correlated with the pathogenesis of depression.

Key words

Depression / DHH gene / Multiple amplification / rs7296288 / Single nucleotide polymorphism site / Highthroughput sequencing / Human

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CHEN Jing-jie WANG Yi-xi LIANG Peng LI Yue1 LI Jian LIANG Yun-dan. Association analysis of DHH gene single nucleotide polymorphism and depression[J]. Acta Anatomica Sinica. 2025, 56(2): 158-162 https://doi.org/10.16098/j.issn.0529-1356.2025.02.005

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