Post-translational modification of integrins and its relationship with  tumor occurrence and development

YANG Jia; WU Xiao; BAO Jin-Suo; CHEN Yi-Ning; ZHANG Hong-Quan; WEI Xiao-Fan

doi:10.16098/j.issn.0529-1356.2025.01.008

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Acta Anatomica Sinica ›› 2025, Vol. 56 ›› Issue (1) : 58-65. DOI: 10.16098/j.issn.0529-1356.2025.01.008

Review

Post-translational modification of integrins and its relationship with tumor occurrence and development

YANG Jia WU Xiao BO Jin-suo CHEN Yi-ning ZHANG Hong-quan WEI Xiao-fan^*

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Abstract

Integrins are transmembrane receptors that can coordinate signal transduction between cells and extracellular matrix or between cells. The abnormal function of integrins is one of the recognized mechanisms of tumor development. As an important regulatory mode, post-translational modification can change the conformation and physicochemical properties of proteins, thus affecting their activities, stability and functions. After the modification of the integrin, such as glycosylation and methylation, the corresponding signal transduction pathway changes, and then affects cell adhesion, migration, differentiation and other life activities, involving in diverse physiology and pathological processes. Post-translational modifications of integrins are abundant in tumor progression and play a key role in regulating the growth, metastasis and drug resistance of different tumor cells. In this review, the structure and function, post-translational modification of integrins, and their relationship with occurrence and development of tumors will be discussed, in order to provide more explorable targets for the treatment of cancer.

Key words

Integrin

/ Post-translational modification / Tumor progression / Cell migration

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YANG Jia WU Xiao BO Jin-suo CHEN Yi-ning ZHNG Hong-quan WEI Xiao-fan. Post-translational modification of integrins and its relationship with tumor occurrence and development[J]. Acta Anatomica Sinica. 2025, 56(1): 58-65 https://doi.org/10.16098/j.issn.0529-1356.2025.01.008

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