Current progress on the role of central nervous system boarder-associated macrophages in brain homeostasis and diseases

SHAO Chen-Shuo; WEI Li-Hang; TAN Guo-He

doi:10.16098/j.issn.0529-1356.2024.04.004

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Acta Anatomica Sinica ›› 2024, Vol. 55 ›› Issue (4) : 399-406. DOI: 10.16098/j.issn.0529-1356.2024.04.004

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Current progress on the role of central nervous system boarder-associated macrophages in brain homeostasis and diseases

SHAO Chen-shuo^1,2WEI Li-hang^1,2TAN Guo-he^1,2*

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Abstract

An increasing number of studies have been focused on the field of immune system in the central nervous system（CNS），as the viewpoint of CNS immune privilege being challenged. Among them, CNS boarder-associated macrophages（BAMs）play a prominent role in the regulation of brain homeostasis and related diseases. Unlike microglia located in the brain parenchyma, BAMs are a type of specialized macrophages located in the meninges (including dura, arachnoid, and leptomeninges) ,perivascular spaces, and choroid plexus. They are crucial for immune surveillance, cerebrospinal fluid drainage, antigen clearance, material exchange, and etc. Here, we reviewed a series of relevant studies on the origin and roles of BAMs in CNS, so as to broaden the understanding of the mechanisms of by which BAMs maintain the brain homeostasis, as well as provide novel insights into the treatment of CNS diseases including Alzheimer 's disease.

Key words

Central nervous system / Boarder-associated macrophage / Cerebrospinal fluid circulation / Homeostasis regulation / Central nervous system diseases

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SHAO Chen-shuo WEI Li-hang TAN Guo-he. Current progress on the role of central nervous system boarder-associated macrophages in brain homeostasis and diseases[J]. Acta Anatomica Sinica. 2024, 55(4): 399-406 https://doi.org/10.16098/j.issn.0529-1356.2024.04.004

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