Meningeal lymphatics: a gateway connecting the central nervous system to peripheral immune system

FAN Rong; LUO Yu-Xiang; GAO Zhi-Hua

doi:10.16098/j.issn.0529-1356.2024.04.003

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Acta Anatomica Sinica ›› 2024, Vol. 55 ›› Issue (4) : 393-398. DOI: 10.16098/j.issn.0529-1356.2024.04.003

Review

Meningeal lymphatics: a gateway connecting the central nervous system to peripheral immune system

FAN Rong¹LUO Yu-xiang²GAO Zhi-hua^2*

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Abstract

Traditionally, the brain was considered as an immune-privileged organ. However, the re-discoveries of meningeal lymphatic vessels have revolutionized our understanding, revealing direct physical and functional connections between the central nervous system and the peripheral immunity. Meningeal lymphatic vessels play a crucial role in draining cerebro-spinal fluid, clearing metabolic waste from the brain, eliciting immune surveillance and maintaining immune homeostasis within the brain. They are implicated in the pathogenesis and progression of multiple central nervous system diseases. This review mainly focuses on the anatomical structure and physiological functions of meningeal lymphatic vessels, with brief introduction to their role in neurological diseases. We summarize recent research advances in meningeal lymphatic vessels, and provide insights for further research and clinical applications.

Key words

Meningeal lymphatic vessel / Glial lymphatic system / Central nervous system disease

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FAN Rong LUO Yu-xiang GAO Zhi-hua. Meningeal lymphatics: a gateway connecting the central nervous system to peripheral immune system[J]. Acta Anatomica Sinica. 2024, 55(4): 393-398 https://doi.org/10.16098/j.issn.0529-1356.2024.04.003

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