Role and research progress of circular RNA in Alzheimer’s disease&nbsp;#br#

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WANG Hong-Fang; GENG Dan-Dan; ZHANG Run-Jiao; LIU Qing; LI Yi-Bo; WANG Lei

doi:10.16098/j.issn.0529-1356.2023.04.017

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Acta Anatomica Sinica ›› 2023, Vol. 54 ›› Issue (4) : 490-494. DOI: 10.16098/j.issn.0529-1356.2023.04.017

Review

Role and research progress of circular RNA in Alzheimer’s disease #br#

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WANG Hongfang¹ GENG Dan-dan^1,2 ZHANG Run-jiao¹ LIU Qing¹ LI Yi-bo¹ WANG Lei^1,2*

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Abstract

The circular RNA (circRNA) is a class of endogenous expressed non-coding RNA that are formed by covalently closed cyclization through reverse splicing. In recent years, a variety of highly conserved and cell-type specific circRNA have been identified in eukaryotes. Alzheimer’s disease (AD) is a common neurodegenerative disease and the most common cause of dementia in the elderly. Recent studies had shown that circRNA was involved in the pathogenesis and development of AD, such as amyloid β-protein (Aβ) metabolic, neuroinflammation, oxidative stress, autophagy and synaptic plasticity. The role and application value of circRNA in AD pathology are reviewed to provide a theoretical basis for the application of circRNA in the treatment and diagnosis of AD.

Key words

Circular RNA / Alzheimer’s disease / Neurodegenerative disease

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WANG Hongfang GENG Dan-dan ZHANG Run-jiao LIU Qing LI Yi-bo WANG Lei. Role and research progress of circular RNA in Alzheimer’s disease #br#

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[J]. Acta Anatomica Sinica. 2023, 54(4): 490-494 https://doi.org/10.16098/j.issn.0529-1356.2023.04.017

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