Molecular mechanism underlying vascular development in the brain

ZHANG Si-Qi; KANG Chen-Xi; ZHANG Pei-Yan; LUO Hai-Xia; LI Fei; SHI Juan; LI Yun-Qing

doi:10.16098/j.issn.0529-1356.2022.05.022

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Acta Anatomica Sinica ›› 2022, Vol. 53 ›› Issue (5) : 680-686. DOI: 10.16098/j.issn.0529-1356.2022.05.022

Review

Molecular mechanism underlying vascular development in the brain

ZHANG Si-qi¹ KANG Chen-xi¹ ZHANG Pei-yan¹ LUO Hai-xia¹ LI Fei^2* SHI Juan^2* LI Yun-qing²

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Abstract

As the pipelines of nutrient and oxygen in the brain, cerebral vessels play an important role in the development and normal function of the brain. The development of the cerebrovascular system is divided into two processes, primitive vasculogenesis and angiogenesis. In this review, we summarize the roles, regulation mechanisms, as well as the interactions of the essential signaling molecules, such as the family members of vascular endothelial growth factor (VEGF), neuropillin, Wnt, Notch, Hedgehog, in the vessel development, aiming to provide a reference for the basic and clinical investigation and the prevention and treatment of vascular diseases.

Key words

Cerebral angiogenesis / Angiogenesis / Vascular endothelial growth factor / Wnt signaling pathway / Notch signaling pathway

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ZHANG Si-qi KANG Chen-xi ZHANG Pei-yan LUO Hai-xia LI Fei SHI Juan LI Yun-qing. Molecular mechanism underlying vascular development in the brain[J]. Acta Anatomica Sinica. 2022, 53(5): 680-686 https://doi.org/10.16098/j.issn.0529-1356.2022.05.022

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