Research progress on the relationship between Nogo protein and myocardial fibrosis

HU Yao-Wen; SUN Yan-Rong; SUN Hao-Zhe; WANG Wen-Juan; ZHANG Su-Xin; QIN Li-Hua

doi:10.16098/j.issn.0529-1356.2022.05.021

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Acta Anatomica Sinica ›› 2022, Vol. 53 ›› Issue (5) : 674-679. DOI: 10.16098/j.issn.0529-1356.2022.05.021

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Research progress on the relationship between Nogo protein and myocardial fibrosis

HU Yao-wen SUN Yan-rong SUN Hao-zhe WANG Wen-juan ZHANG Su-xin QIN Li-hua*

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Abstract

Nogo protein is the fourth member of reticulin family. Nogo mRNA produced by encoding gene transcription, forms three different RNA transcripts due to different promoter and splicing modes, namely Nogo-A, Nogo-B and Nogo-C protein. Nogo protein was first found in the central nervous system, and then proved to be widely expressed in peripheral tissues such as heart, liver and vascular endothelium. Studies have shown that Nogo protein can participate in the regulation of myocardial fibrosis through RhoA/Rho-associated kinase(ROCK) pathway, endoplasmic reticulum stress, Sce61 α and other signaling pathways. In this paper, the relationship between Nogo-A, Nogo-B, Nogo-C and myocardial fibrosis is briefly introduced.

Key words

Nogo-A / Nogo-B / Nogo-C / Myocardial fibrosis

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HU Yao-wen SUN Yan-rong SUN Hao-zhe WANG Wen-juan ZHANG Su-xin QIN Li-hua. Research progress on the relationship between Nogo protein and myocardial fibrosis[J]. Acta Anatomica Sinica. 2022, 53(5): 674-679 https://doi.org/10.16098/j.issn.0529-1356.2022.05.021

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