Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain

TANG Xiao-Lu; DENG Cong-Cong; WANG Pei; CHEN Ming-Hui; TIAN Kai; SU Yan-Yan; MA Hui; WU Xue-Yan; SHEN Yu-Xian

doi:10.16098/j.issn.0529-1356.2022.05.002

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Acta Anatomica Sinica ›› 2022, Vol. 53 ›› Issue (5) : 551-556. DOI: 10.16098/j.issn.0529-1356.2022.05.002

Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain

TANG Xiao-lu¹ DENG Cong-cong² WANG Pei¹ CHEN Ming-hui³ TIAN Kai⁴ SU Yan-yan¹ MA Hui⁵ WU Xue-yan^1* SHEN Yu-xian^6,7*

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Abstract

Objective To observe the distribution of mesencephalic astrocyte derived neurotrophic factor (MANF) within the brain in human, mice and rats and the comparison across the species. Methods An immunohistochemical method was applied to investigate the expression of MANF and to compare the differences among species in the brain of human specimens (n=5), mice (n=6), and rats (n=6). Results The expression of MANF varied in different brain regions in human, mice and rats. In human, in the cortex, the expression of MANF was the highest among all brain regions. In the subcortical areas or the nucleus, brainstem and cerebellum expression level of MANF were relatively lower. The distribution of MANF in mouse and rat brain were slightly different from that in human brain, but generally consistent. Conclusion The distribution pattern of MANF is similar across the species, however, within a species, MANF expression levels varies in different brain regions.

Key words

Mesencephalic astrocyte derived neurotrophic factor / Brain distribution / Immunohistochemistry / Human / Rat / Mouse

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TANG Xiao-lu DENG Cong-cong WANG Pei CHEN Ming-hui TIAN Kai SU Yan-yan MA Hui WU Xue-yan SHEN Yu-xian. Distribution of mesencephalic astrocyte derived neurotrophic factor in human, mouse and rat brain[J]. Acta Anatomica Sinica. 2022, 53(5): 551-556 https://doi.org/10.16098/j.issn.0529-1356.2022.05.002

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