Distribution of Nogo in the heart and its role in cardiovascular disease

ZHANG Su-xin SUN Yan-rong WANG Wen-juan SUN Hao-zhe HU Yao-wen QIN Lin-hua

Acta Anatomica Sinica ›› 2021, Vol. 52 ›› Issue (3) : 495-498.

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Acta Anatomica Sinica ›› 2021, Vol. 52 ›› Issue (3) : 495-498. DOI: 10.16098/j.issn.0529-1356.2021.03.026
Review

Distribution of Nogo in the heart and its role in cardiovascular disease

  • ZHANG Su-xin1  SUN Yan-rong2  WANG Wen-juan2  SUN Hao-zhe3  HU Yao-wen1  QIN Lin-hua2*
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Abstract

As a member of the reticulin family, Nogo is mainly involved in processes such as tissue regeneration, apoptosis and tumor growth after tissue injury. Cardiovascular disease is one of the main diseases that threaten human health at present. In recent years, research on Nogo in the cardiovascular system has become increasingly extensive. Changes in the expression of Nogo during myocardial fibrosis, myocardial cell apoptosis and vascular remodeling suggest that it may play a certain role. This article reviews the distribution of Nogo in the heart and its role in cardiovascular disease, in order to reveal its possible role and mechanism in cardiovascular diseases.

Key words

Nogo / Myocardial infarction / Heart failure / Myocardial apoptosis / Myocardial fibrosis / Coronary vascular regulation

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ZHANG Su-xin SUN Yan-rong WANG Wen-juan SUN Hao-zhe HU Yao-wen QIN Lin-hua. Distribution of Nogo in the heart and its role in cardiovascular disease[J]. Acta Anatomica Sinica. 2021, 52(3): 495-498 https://doi.org/10.16098/j.issn.0529-1356.2021.03.026

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