Relationship between exercise and bone strength, body composition, sex hormones in postmenopausal women

YE Zhen-Zhen; YI Jian-Feng

doi:10.16098/j.issn.0529-1356.2021.03.022

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Acta Anatomica Sinica ›› 2021, Vol. 52 ›› Issue (3) : 473-478. DOI: 10.16098/j.issn.0529-1356.2021.03.022

Anthropology

Relationship between exercise and bone strength, body composition, sex hormones in postmenopausal women

YE Zhen-zhen¹YI Jian-feng^2* PAN Jian-xi³

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Abstract

Objective To investigate the effects of exercise on bone strength, body composition, sex hormones and their relationship in postmenopausal women of Han nationality in Lanzhou. Methods From Jan. 2018 to Jun. 2019, 233 cases postmenopausal women of Han nationality in Lanzhou (110 cases in exercise group and 123 cases in non exercise group) were selected by stratified random sampling method , whose bone strength, body composition indexes and sex hormone were measured by ultrasonic bone mineral density meter, body composition analyzer and electrochemiluminescence automatic immune analyzer, respectively. Results There were lower body weight, body mass index and fat tissue composition of postmenopausal women of Lanzhou Han nationality (P<0.05), and there was higher bone strength, estradiol and muscle tissue composition in the exercise group (P<0.01). The prevalence of osteoporosis and obesity was lower in the exercise group (P<0.01). Pearson correlation analysis showed that estradiol and muscle tissue composition were positively correlated with the bone strength (P<0.05), and it was negatively correlated with fat tissue composition in postmenopausal women (P<0.01). Logistic regression analysis showed that limb muscle mass and estradiol were protective factors for bone, and visceral fat content was the risk factor of bone abnormality in postmenopausal non-exercise women. Estrogen was the protective factor of bone in postmenopausal exercise women. Conclusion The bone strength of postmenopausal women is determined by muscle and fat tissue, and the relationship between the both is affected by exercise. Exercise could effectively prevent and control osteoporosis in postmenopausal women of Lanzhou Han nationality by promoting estrogen production, increasing limb muscle and reducing visceral fat mass.

Key words

Bone strength / Body composition / Sex hormone / Exercise / Bioelectrical impedance analysis / Postmenopausal woman

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YE Zhen-zhen YI Jian-feng PAN Jian-xi. Relationship between exercise and bone strength, body composition, sex hormones in postmenopausal women[J]. Acta Anatomica Sinica. 2021, 52(3): 473-478 https://doi.org/10.16098/j.issn.0529-1356.2021.03.022

References

［1］ The Osteoporosis Committee of China Gerontological Society. Expert consensus on the diagnosis of osteoporosis in Chinese Population (in 2014) ［J］. Chinese Journal of Osteoporosis, 2014, 20 (9): 1007-1010. (in Chinese)

中国老年学学会骨质疏松委员会. 中国人骨质疏松症诊断标准专家共识(2014) ［J］. 中国骨质疏松杂志, 2014, 20(9): 1007-1010.

［2］ Chinese Society of Osteoporosis and Bone Mineral Research． Guidelines for the diagnosis and treatment of primary osteoporosis (2017) ［J］. Chinese Journal of Osteoporosis and Bone Mineral Diseases, 2017, 20(5): 413-443. (in Chinese)

中华医学会骨质疏松和骨矿盐疾病分会. 原发性骨质疏松症诊疗指南(2017) ［J］. 中华骨质疏松和骨矿盐疾病杂志, 2017, 20(5): 413-443.

［3］ Ye ZhZh, Yi JF, Pan JX, et al. Characteristics and relationship of bone strength and body composition in pre-and post-menopausal Dongxiang women ［J］. Acta Anatomica Sinica, 2019, 50(5): 656-661. (in Chinese)

叶蓁蓁, 易剑锋, 潘建西，等. 东乡族成年女性绝经前后骨强度和体成分特征及其相关性［J］. 解剖学报, 2019, 50(5): 656-661.

［4］ Li GW, Chang ShX, Fan JZh, et al. Relationship between body composition and bone strength in postmenopausal women ［J］. Chinese Journal of Osteoporosis, 2013, 19(7): 681-685. (in Chinese)

李冠武, 常时新, 范敬争, 等. 绝经后女性体成分与骨强度的相关性研究［J］. 中国骨质疏松杂志, 2013, 19(7): 681-685.

［5］ Ho-Pham LT, Nguyen ND, Lai TQ, et al. Contributions of lean mass and fat mass to bone mineral density: a study in postmenopausal women ［J］. BMC Musculoskelet Disord, 2010, 11(1):59-60.

［6］ Shao J, Zhang Y, Yang T, et al. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression ［J］. In Vitro Cell Dev Biol Anim, 2015, 51(8): 808-814.

［7］ Yin X, Wang X, Hu X, et al. ERβ induces the differentiation of cultured osteoblasts by both Wnt/β-catenin signaling pathway and estrogen signaling pathways ［J］. Exp Cell Res, 2015, 335(1): 107-114.

［8］ Cyril T, Joseph C. Ablation of p38α MAPK Signaling in osteoblast lineage cells protects mice from bone loss induced by estrogen deficiency［J］. Endocrinology, 2015, 156(12): 4377-4387.

［9］ Zhao C, Li J, Cheng MH, et al. Estrogen maintains skeletal muscle in septic rats associated with altering hypothalamic inflammation and neuropeptides ［J］. Horm Metab Res, 2017, 49(3): 221-228.

［10］ Vasconsuelo A, Milanesi L, Boland MR. Participation of HSP27 in the antiapoptotic action of 17β-estradiol in skeletal muscle cells ［J］. Cell Stress Chaperones, 2010, 15(2): 183-192.

［11］ Diel P. The role of the estrogen receptor in skeletal muscle mass homeostasis and regeneration ［J］. Acta Physiol, 2014, 212(1): 14-16.

［12］ Orsatti FL, Maestá N, de Oliveira EP, et al. Adding soy protein to milk enhances the effect of resistance training on muscle strength in postmenopausal women ［J］. J Diet Suppl, 2018, 15(2): 140-152.

［13］ Chen XL. Intervention and mechanism of exercises on primary osteoporosis ［J］. Chinese Journal of Tissue Engineering Research, 2018, 22(8): 1294-1299. (in Chinese)

陈鑫林. 运动对原发性骨质疏松症的干预与机制［J］. 中国组织工程研究, 2018, 22(8): 1294-1299.

［14］ Crawford RP, Cann CE, Keaveny TM. Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography ［J］. Bone, 2003, 33(4): 744-750.

［15］ Qin QS, Wang DM, Ma LT, et al. Characteristics of bone strength index and its relationship with body composition in Lanzhou Han nationality adults ［J］. Acta Anatomica Sinica, 2016, 47(6): 838-842. (in Chinese)

秦青松, 汪东梅, 马路通, 等. 兰州市汉族成人骨强度指数特点及其与体成分的关系［J］. 解剖学报, 2016, 47(6):838-842.

［16］ Coorperative Meta-analysis Group of China Obesity Task Force. Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population ［J］. Chinese Journal of Epidemiology, 2002, 23(1): 5-10. (in Chinese)

中国肥胖问题工作组数据汇总分析协作组. 我国成人体重指数和腰围对相关疾病危险因素异常的预测价值：适宜体重指数和腰围切点的研究［J］. 中华流行病学杂志, 2002, 23(1): 5-10.

［17］ Spangenberg, A, Maghsoodi, N, Dulnoan, D, et al. Bone mineral density and body composition are associated with circulating angiogenic factors in post-menopausal women ［J］. Calcif Tissue Int, 2016, 99(6): 608-615.

［18］ Giangregorio L, Blimkie CJR. Skeletal adaptations to alterations in weight-bearing activity ［J］. Sports Medicine, 2002, 32(7): 459-476.

［19］ Frost HM. Skeletal structural adaptations to mechanical usage (SATMU): 2. Redefining Wolff’s Law: the remodeling problem ［J］. Anat Record, 1990, 226(4): 414-422.

［20］ Reid IR. Relationships among body mass, its components, and bone［J］. Bone, 2002, 31(31): 547-555.

［21］ Elefteriou F, Ahn JD, Shu T, et al. Leptin regulation of bone resorption by the sympathetic nervous system and CART［J］. Nature, 2005, 434(7032): 514-520.

［22］ Ilich JZ, Kelly OJ, Inglis JE, et al. Interrelationship among muscle, fat, and bone: Connecting the dots on cellular, hormonal, and whole body levels［J］. Ageing Res Rev, 2014, 15(4):51-60.

［23］ Akune T, Ohba S, Kamekura S, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors ［J］. J Clin Invest, 2004, 113(6): 846-855.

［24］ Yang XL, He Y, Ma B, et al. Analysis of the body composition of adult Tibetans in Gansu and Tibet ［J］. Acta Anatomica Sinica, 2016, 47(1): 134-138. (in Chinese)

杨秀琳, 何烨, 马斌, 等.甘肃及西藏藏族成人体成分分析［J］. 解剖学报,2016, 47(1): 134-138.

［25］ Yi JF, Yang T, Ye ZhZh, et al. Characteristics of bone strength and body composition in Gansu Yugur adults and correlation analysis ［J］. Acta Anatomica Sinica, 2017, 48(4): 471-476. (in Chinese)

易剑锋, 杨涛, 叶蓁蓁, 等. 甘肃裕固族成人骨强度和体成分变化特点及相关性分析［J］. 解剖学报, 2017, 48(4): 471-476.

［26］ Tian XY. Effects of exercise on the expression of aromatase and the activated of protein signaling pathways in skeletal muscle ［D］. Shanghai：Shanghai Institute of physical education, 2017. (in Chinese)

田向阳. 运动对去卵巢大鼠骨骼肌芳香化酶及其相关信号通路蛋白的影响［D］. 上海：上海体育学院, 2017.

［27］ La Colla A, Vasconsuelo A, Milanesi L, et al. 17β-estradiol protects skeletal myoblasts from apoptosis through p53, Bcl-2, and FoxO families ［J］. J Cell Biochem, 2017, 118(1): 104-115.

［28］ Fan JZh, Yang L, Luo ZhJ, et al. Impact of estrogen on the Notch signaling pathway in human bone mesenchymal stem cells derived from patients with postmenopausal osteoporosis ［J］. Chinese Journal of Osteoporosis and Bone Mineral Diseases, 2013, 6(3): 232-239. (in Chinese)

范金柱, 杨柳, 罗卓荆,等. 雌激素对绝经后骨质疏松患者骨髓间充质干细胞Notch信号通路的影响［J］. 中华骨质疏松和骨矿盐疾病杂志, 2013, 6(3): 232-239

［29］ Wang B, Shi Q. Effects of long-term aerobic exercise on endogenous hydrogen sulfide production in bone tissue of ovariectomized rats ［J］. Chinese Journal of Gerontology, 2018, 38 (11): 160-162. (in Chinese)

王兵, 石琼. 长期有氧运动对去卵巢大鼠骨组织中内源性硫化氢生成的影响［J］. 中国老年学杂志, 2018, 38(11):160-162.

［30］ Barros RPA, Gabbi C, Morani A, et al. Participation of ER and ERβ in glucose homeostasis in skeletal muscle and white adipose tissue ［J］. Am J Physiol Endocrinol Metab, 2009, 297(1): E124-133.

［31］ Damien E, Price JS, Lanyon LE. Mechanical strain stimulates osteoblast proliferation through the estrogen receptor in males as well as females ［J］. Journal of Bone and Mineral Research, 2000, 15(11): 2169-2177.