Correlation between serum angiotensin converting enzyme and angiotensinogen levels and pregnancy-induced hypertension and analysis of risk factors

WANG Ru; ZHUANG Wen-Ting; WANG Xiang-Lin; LI Jian-Hua; LI Hong-Rong; LI Chang-Xing; KONG De-Xia

doi:10.16098/j.issn.0529-1356.2021.03.020

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Acta Anatomica Sinica ›› 2021, Vol. 52 ›› Issue (3) : 460-464. DOI: 10.16098/j.issn.0529-1356.2021.03.020

Correlation between serum angiotensin converting enzyme and angiotensinogen levels and pregnancy-induced hypertension and analysis of risk factors

WANG Ru¹ ZHUANG Wen-ting¹ WANG Xiang-lin² LI Hong-rong³ LI Chang-xing¹ KONG De-xia⁴ LI Jian-hua^1*

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Abstract

Objective To investigate the relationship between serum angiotensin converting enzyme (ACE) and angiotensinogen (AGT) and gestational hypertension syndrome (HDCP) and the risk factors of HDCP. Methods A total of 135 pregnant hypertensive patients (HDCP group) and 100 normal pregnant women as control check (CK) group were selected. Serum ACE and AGT levels were measured by ELISA, and correlation analysis was performed. The age and gestational age of the two groups, prepregnancy body mass index (BMI), parity, number of births, family history of hypertension, family history, education, and other general information, single factor analysis of risk factors for maternal HDCP, single factor regression analysis Statistically significant factors were all used for multivariate logistic regression analysis. Results The serum ACE level in the HDCP group (90.49±47.65)μg/L was significantly higher than that in the CK group (58.72±27.58)μg/L, P<0.05, the difference was statistically significant. The serum AGT level in the HDCP group was (64.57±19.71)μg/L was higher than CK group (58.22±18.64)μg/L, P>0.05, the difference was not statistically significant; single factor analysis showed: age, BMI, hypertension, family history of diabetes, ACE level was maternal (P<0.05), while gestational age, parity, number of births, and education were no significant differences in risk factors for HDCP (P>0.05). Multivariate analysis showed: age, BMI, history of hypertension and ACE. It was a risk factor for pregnancy-induced hypertension. Conclusion ACE levels are associated with HDCP. AGT levels are not associated with HDCP. Patients with a high age, high BMI, and hypertension history have an increased risk of gestational hypertension syndrome.

Key words

Pregnancy-induced hypertension / Risk factor / Angiotensin-converting enzyme / Angiotensinogen / Enzyme linked immunosorbent assay / Human

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WANG Ru ZHUANG Wen-ting WANG Xiang-lin LI Hong-rong LI Chang-xing KONG De-xia LI Jian-hua. Correlation between serum angiotensin converting enzyme and angiotensinogen levels and pregnancy-induced hypertension and analysis of risk factors[J]. Acta Anatomica Sinica. 2021, 52(3): 460-464 https://doi.org/10.16098/j.issn.0529-1356.2021.03.020

References

［1］ WHO Recommendations: Policy of Interventionist Versus Expectant Management of Severe Pre-eclampsia Before Term［M］.Geneva: World Health Organization, 2018:7．

［2］ ACOG Practice Bulletin No.202: Gestational hypertension and preeclampsia［J］.Obstet Gynecol,2019,133(1):e1-e25

［3］ Al-Jameil N, Khan FA, Khan MF, et al. A brief overview of preeclampsia［J］. J Clin Med Res, 2014, 6(1):1-7.

［4］ Palomaki GE, Haddow JE, Haddow HRM, et al. Modeling risk for severe adverse outcomes using angiogenic factor measurements in women with suspected preterm preeclampsia［J］. Prenat Diagn, 2015, 35(4):386-393.

［5］ Baltajian K, Bajracharya S, Salahuddin S, et al. Sequential plasma angiogenic factors levels in women with suspected preeclampsia［J］. Am J Obstet Gynecol, 2016,215(1):89.e1-e10.

［6］ Ren YF, Jiang YJ, Zhang XL, et al. Effects of SHH signaling pathway on trophoblast apoptosis and invasion in preeclampsia patients and its mechanism［J］. Journal of Jilin University (Medicine Edition), 2018, 271(3):56-61.（in Chinese）

任艳芳, 姜永杰, 张秀玲, 等. SHH信号通路对子痫前期患者滋养细胞凋亡和侵袭的影响及其机制［J］. 吉林大学学报(医学版), 2018, 271(3):56-61.

［7］ His W. Reni-angiotensin-aldosterone system in the pathogenesis of pregnancy-induced hypertension［J］. Exp Clin Endocrinol Diabetes, 2018, 126(6):362-366.

［8］ Eugenia MG, Blood AB, Sands LD, et al. A novel rodent model of pregnancy complications associated with genetically determined angiotensin-converting enzyme (ACE) activity［J］. Am J Physiol Endocrinol Metab, 2018, 315(1):E52-E62.

［9］ González-Garrido JA, García-Sánchez JR, Tovar-Rodríguez JM, et al. Preeclampsia is associate with ACE I/D polymorphism obesity and oxidative damage in Mexican women［J］.Pregnancy Hypertens, 2017,10:22-27.

［10］ Elliot MG. Oxidative stress and the evolutionary origins of preeclampsia［J］. J Reprod Immunol, 2016,114(4):75-80.

［11］ Zhou X, Zhang P, Liang T, et al. Relationship between circulating levels of angiotensin-converting enzyme 2-angiotensin-(1-7)-MAS axis and coronary heart disease［J］. Heart Vessels, 2020, 35（2）:153-161.

［12］ González-Garrido José A, García-Sánchez José R, Tovar-Rodríguez José M, et al. Preeclampsia is associate with, ACE, I/D polymorphism, obesity and oxidative damage in Mexican Women［J］. Pregnancy Hypertension, 2017,10:22-27

［13］ Xiang ZhH, Jiang XD, Zhang Y, et al. Significance of detecting angiotensin-converting enzyme in predicting pregnancy-induced hypertension syndrome in the second trimester of pregnancy［J］.Labeled Immunoassays and Clinical Medicine, 2018, 25(9): 17-19. (in Chinese)

项舟弘,蒋秀娣,张杨,等.孕中期检测血管紧张素转化酶对预测妊娠高血压综合征的意义［J］.标记免疫分析与临床, 2018, 25(9):17-19

［14］ Al-Jameil N, Khan FA, Khan MF, et al. A brief overview of preeclampsia［J］. J Clin Med Res, 2014, 6(1):1-7.

［15］ Jim B, Karumanchi SA. Preeclampsia: pathogenesis, prevention, and long-term complications［J］. Semin Nephrol, 2017, 37(4):386-397.

［16］ Gan B, Yang YY, Li M, et al. Analysis of risk factors for preeclampsia［J］. Chinese Journal of Obstetrics and Gynecology, 2013(6): 540-542.(in Chinese)

甘冰, 杨燕嫣, 李敏,等.子痫前期发病危险因素分析［J］. 中国妇产科临床杂志, 2013(6):540-542.

［17］ Sibai B. Diagnosis and management of atypical preeclampsia-eclampsia［J］. Am J Obstet Gynecol, 2009, 200(5):481.e1-e7.

［18］ Sheng N, Song WQ. Progress in the risk factors of preeclampsia in hypertensive pregnancy［J］. World Medical Information Digest, 2019, 19(27): 51-75.(in Chinese)

胜楠, 宋伟奇. 妊娠高血压子痫前期发病危险因素研究进展［J］. 世界最新医学信息文摘, 2019, 19(27):51-75.

［19］ Staff AC, Benton SJ, von Dadelszen P, et al. Redefining preeclampsia using placenta-derived biomarkers［J］.Hypertension,2013,61(5):932-942.

［20］ Spiel M, Salahuddin S, Pernicone E, et al. Placental soluble fms-like tyrosine kinase expression in small for gestational age infants and risk for adverse outcomes［J］. Placenta, 2017, 52:10-16.