Outcomes of frozen-thawed embryo transfer cycles of progestin-primed ovarian stimulation protocol compared with other three ovulation hyperstimulation protocols

LI Jian-Hua; JIAO Ting-Ting; WANG Jian-Ye; LI Chang-Shan; DONG Pan; CHEN Xi; ZHANG Shui-Wen

doi:10.16098/j.issn.0529-1356.2021.02.019

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Acta Anatomica Sinica ›› 2021, Vol. 52 ›› Issue (2) : 284-288. DOI: 10.16098/j.issn.0529-1356.2021.02.019

Histology,Embryology and Developmental Biology

Outcomes of frozen-thawed embryo transfer cycles of progestin-primed ovarian stimulation protocol compared with other three ovulation hyperstimulation protocols

LI Jian-hua¹ JIAO Ting-ting¹ WANG Jian-ye¹ LI Chang-shan¹ DONG Pan¹ CHEN Xi^2* ZHANG Shui-wen^1*

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Abstract

Objective To analyze the clinical outcomes of progestin primed ovarian stimulation (PPOS) compared with the other three different controlled ovarian hyperstimulation (COH) protocols in fresh embryo transfer (ET) and frozen-thawed embryo transfer (FET) cycles. Methods A total of 430 oocyte pickup cycles and 272 FET cycles were retrospectively analyzed. Number of oocytes retrieved, laboratory indexes and pregnancy outcome of FET were compared. Results The mean oocytes retrieved (11.1±7.3), fertilization rate (85.6%), cleavage rate (95.1%) and excellent embryo rate (20.2%) as well as transplantable embryo rate (4.5±3.1) of the PPOS group did not show significant differences compared with the other 3 subgroups (all P<0.05) in fresh cycle. As for pregnancy outcomes in FET cycles, no statistically significant differences were observed among the four groups in embryo implantation rate (26.2%), clinical pregnancy rate (63.0%) and abortion rate (11.8%) (all P<0.05)．However, embryo implantation rate, clinical pregnancy rate was higher in PPOS group compared with the other groups. Conclusion Conclusion Compared with the other three ovulation stimulation programme, PPOS might be used as a new alternative for controlled ovulation stimulation protocols.

Key words

Controlled ovarian hyperstimulation

/ Progestin primed ovarian stimulation / Frozen-thawed embryo transfer / Clinical pregnancy rate / In vitro fertilization / Intracytoplasmic sperm injection / Female

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LI Jian-hua JIAO Ting-ting WANG Jian-ye LI Chang-shan DONG Pan CHEN Xi ZHANG Shui-wen. Outcomes of frozen-thawed embryo transfer cycles of progestin-primed ovarian stimulation protocol compared with other three ovulation hyperstimulation protocols[J]. Acta Anatomica Sinica. 2021, 52(2): 284-288 https://doi.org/10.16098/j.issn.0529-1356.2021.02.019

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