Progress of microRNAs in planarian regeneration

ZHANG Fen-Xi; DONG Zi-Mei; CHEN Guang-Wen; LIU De-Zeng

doi:10.16098/j.issn.0529-1356.2020.04.026

PDF(1389 KB)

Acta Anatomica Sinica ›› 2020, Vol. 51 ›› Issue (4) : 631-636. DOI: 10.16098/j.issn.0529-1356.2020.04.026

Review

Progress of microRNAs in planarian regeneration

ZHANG Fen-xi DONG Zi-me, CHEN Guang-wen* LIU De-zeng

Author information +

History +

Abstract

Planarians have strong regenerative ability, which mainly results from the adult stem cells-neoblasts in their body. Currently, planarians have been an important model organism in the research on regeneration science, and neoblasts have also been the tool cells in biomedical research. But, the scientists still do not find the gene system that effectively regulates planarian regeneration and neoblast proliferation until now. MicroRNAs (miRNAs) are a kind of endogenous, small and noncoding RNAs widely expressed in eukaryotes. MiRNAs can negatively regulate expression of functional genes through specifically recoganizing and binding the target genes. Recently, a few studies have indicated that microRNAs may participate in planarian regeneration. In this review, we will summarize the new progress on miRNAs regulating planarian regeneration as well as neoblast proliferation and differentiation.

Key words

MicroRNA / Planarian / Neoblast / Proliferation / Regeneration

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

ZHANG Fen-xi DONG Zi-me, CHEN Guang-wen LIU De-zeng. Progress of microRNAs in planarian regeneration[J]. Acta Anatomica Sinica. 2020, 51(4): 631-636 https://doi.org/10.16098/j.issn.0529-1356.2020.04.026

References

［1］ Dong ZM, Li XY, Chen J, et al. Review on the genes involved in eyes morphogenesis in freshwater planarian ［J］. Acta Anatomica Sinica, 2015, 46(3): 422-427. (in Chinese)
董自梅, 李小艳, 陈静,等. 淡水涡虫眼点形态发生相关基因研究进展［J］. 解剖学报, 2015,46(3): 422-427.
［2］ Gehrke AR, Srivastava M. Neoblasts and the evolution of whole-body regeneration ［J］. Curr Opin Genet Dev, 2016,40:131-137.
［3］ Tran TA, Gentile L. A lneage CLOUD for neoblasts ［J］. Semin Cell Dev Biol, 2019, 87: 22-29.
［4］ Lee RC, Feinbaum RL, Ambros Ⅴ. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementary to lin-4 ［J］. Cell, 1993, 75(5): 843-854.
［5］ Reis RS. The entangled history of animal and plant microRNAs ［J］. Funct Integr Genomics, 2016, 17(23): 127-134.
［6］ Kim DY, Sung JH. Regulatory role of microRNAs in the proliferation and differentiation of adipose-derived stem cells ［J］. Histol Histopathol, 2017, 32(1): 1-10.
［7］ Palakodeti D, Smielewska M, Graveley BR. MicroRNAs from the planarian schmidtea mediterranea: a model system for stem cell biology ［J］. RNA, 2006, 12(9): 1640-1649.
［8］ Krishna S, Palakodeti D, Solana J. Post-transcriptional regulation in planarian stem cells ［J］. Semin Cell Dev Biol, 2019, 87: 69-78.
［9］ Karami A, Tebyanian H, Goodarzi Ⅴ, et al. Planarians: an in vivo model for regenerative medicine ［J］. Int J Stem Cells, 2015, 8(2): 128-133.
［10］ Wagner DE, Wang IE, Reddien PW. Clonogenic neoblasts are pluripotent adult stem cells that underlie planarian regeneration ［J］. Science, 2011, 332(6031): 811-816.
［11］ Sánchez Alvarado A, Kang H. Multicellularity, stem cells, and the neoblasts of the planarian Schmidtea mediterranea ［J］. Exp Cell Res, 2005, 306(2): 299-308.
［12］ Wang ST, Chen GW, Xu XSh, et al. Research progress of stem cells in planarians ［J］. Basic & Clinical Medicine, 2009, 29(1): 93-96. (in Chinese)
王松涛, 陈广文, 徐存拴, 等. 涡虫干细胞研究进展［J］. 基础医学与临床研究, 2009, 29(1): 93-96.
［13］ Gentile L, Cebriá F, Bartscherer K. The planarian flatworm: an in vivo model for stem cell biology and nervous system regeneration ［J］. Dis Model Mech, 2011, 4(1): 12-19.
［14］ Wenemoser D, Reddien PW. Planarian regeneration involves distinct stem cell response to wounds and tissue absence ［J］. Dev Biol, 2010, 344(2): 979-991.
［15］ Rink JC. Stem cell systems and regeneration in planaria ［J］. Dev Genes Evol, 2013, 223(1-2): 67-84.
［16］ Reddien PW. Specialized progenitors and regeneration ［J］. Development, 2013, 140(5): 951-957.
［17］ Betchaku T. Isolation of planarian neoblasts and their behavior in vitro with some aspects of the mechanism of the formation of regeneration blastema ［J］. J Exp Zool, 1967, 164(3): 407-433.
［18］ Hayashi T, Asami M, Higuchi S, et al. Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting ［J］. Dev Growth Differ, 2006, 48(6): 371-380.
［19］ Gulyaeva LF, Kushlinskiy NE. Regulatory mechanisms of microRNA expression ［J］. J Transl Med, 2016, 14(1): 143.
［20］ Thatcher EJ, Paydar I, Anderson KK, et al. Regulation of zebrafish fin regeneration by microRNAs ［J］. Proc Natl Acad Sci USA, 2008, 105(47): 18384-18389.
［21］ Spina EJ, Guzman E, Zhou H, et al. A microRNA-mRNA expression network during oral siphon regeneration in Ciona ［J］. Development, 2017, 144(10): 1787-1797.
［22］ Peterson KJ, Dietrich MR, McPeek MA. MicroRNAs and metazoan macroevolution: insights into canalization, complexity, and the Cambrian explosion ［J］. Bioessays, 2009, 31(7): 736-747.
［23］ Axtell MJ, Westholm JO, Lai EC. Vive la difference: biogenesis and evolution of microRNAs in plants and animals ［J］. Genome Biol, 2011, 12(4): 221.
［24］ Rodriguez A, GriffithsJones S, Ashurst JL, et al. Identification of mammalian microRNA host genes and transcription units ［J］. Genome Res, 2004, 14(10A): 1902-1910.
［25］ Lee RC, Ambros V. An extensive class of small RNAs in Caenorhabditis elegans ［J］. Science, 2001, 294 (5543): 862-864.
［26］ Saraiva C, Esteves M, Bernardino L. MicroRNA: Basic concepts and implications for regeneration and repair of neurodegenerative diseases ［J］. Biochem Pharmacol, 2017, 141: 118-131.
［27］ Fang S, Deng Y, Gu P, et al. MicroRNAs regulate bone development and regeneration ［J］. Int J Mol Sci, 2015, 16(4):8227-8253.
［28］ Walker SE, Spencer GE, Necakov A, et al. Identification and characterization of microRNAs during retinoic acid-induced regeneration of a molluscan central nervous system ［J］. Int J Mol Sci, 2018, 19(9): E2741.
［29］ Fuller-Carter PI, Cater KW, Anderson D, et al. Integrated analyses of zebrafish miRNA and mRNA expression profiles identify miR-29b and miR-223 as potential regulators of optic nerve regeneration ［J］. BMC Genomics, 2015, 16: 591.
［30］ Kim CW, Han JH, Wu L, et al. MicroRNA-183 is essential for hair cell regeneration after neomycin injury in zebrafish ［J］. Yonsei Med J, 2018, 59(1): 141-147.
［31］ Wagner DE, Ho JJ, Reddien PW. Genetic regulators of a pluripotent adult stem cell system in planarians identified by RNAi and clonal analysis ［J］. Cell Stem Cell, 2012, 10(3): 299-311.
［32］ Shim J, Nam JW. The expression and functional roles of microRNAs in stem cell differentiation ［J］. BMB Rep, 2016, 49(1): 3-10.
［33］ Tian QN, Bao ZX, Lu P, et al. Differential expression of microRNA patterns in planarian normal and regenerative tissues ［J］. Mol Biol Rep, 2012, 39(3): 2653-2658.
［34］ Wu YY, Zhao JM, Liu Q, et al. miR-71b regulation of insulin/IGF-1 signaling during starvation in planarians ［J］. Genet Mol Res, 2015, 14(14): 11905-11914.
［35］ Sasidharan V, Lu YC, Bansal D, et al. Identification of neoblast-and regeneration-specific miRNAs in the planarian Schmidtea mediterranea ［J］. RNA, 2013, 19(10): 1394-1404.
［36］ Sasidharan V, Marepally S, Elliot SA, et al. The miR-124 family of microRNAs is crucial for regeneration of the brain and visual system in the planarian Schmidtea mediterranea ［J］. Development, 2017, 144(18): 3211-3223.
［37］ González-Estévez C, Arseni V, Thambyrajah RS, et al. Diverse miRNA spatial expression patterns suggest important roles in homeostasis and regeneration in planarians ［J］. Int J Dev Biol, 2009, 53(4): 493-505.
［38］ Li Y, Zeng A, Han XS, et al. Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarian Schmidtea mediterranea ［J］. Genom Data, 2017, 14: 114-125.