Monoamine neurotransmitter theories of menopausal hot flashes

SUN Yan-rong YANG Qi-yue LI Yao WANG Wen-juan WANG Ke QIN Li-hua*

doi:10.16098/j.issn.0529-1356.2019.06.029

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Acta Anatomica Sinica ›› 2019, Vol. 50 ›› Issue (6) : 857-860. DOI: 10.16098/j.issn.0529-1356.2019.06.029

Review

Monoamine neurotransmitter theories of menopausal hot flashes

SUN Yan-rong¹ YANG Qi-yue¹ LI Yao² WANG Wen-juan¹ WANG Ke¹ QIN Li-hua^1*

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Abstract

Hot flashes are the most common symptoms of menopausal women, and their symptoms are closely related to the occurrence of cardiovascular disease, which seriously affects the physical and mental health of menopausal women. Therefore, avoiding and alleviating the occurrence of hot flashes during menopause has become a topic of great concern today. It is generally believed that the hot flashes are caused by the dysfunction of hypothalamic thermoregulatory center, but its exact pathogenesis has not been elucidated. Recent studies have shown that menopausal hot flashes are the result of the interaction of estrogen with a variety of neurotransmitters, and monoamine neurotransmitters like norepinephrine, 5-hydroxytryptamine and dopamine play a central role, which are summarized as follows.

Key words

Hot flash / Estrogen / Norepinephrine / 5-hydroxytryptamine / Dopamine

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SUN Yan-rong YANG Qi-yue LI Yao WANG Wen-juan WANG Ke QIN Li-hua. Monoamine neurotransmitter theories of menopausal hot flashes[J]. Acta Anatomica Sinica. 2019, 50(6): 857-860 https://doi.org/10.16098/j.issn.0529-1356.2019.06.029

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