Objective Observing the application of the combination of virtuality and reality in the experimental teaching of the anatomy of motor system. Methods Two classes were randomly selected from the class of 2017 clinical 5-year students in Fenyang College of Shanxi Medical University, one class was the experimental group, implemented the teaching mode of the combination of body specimen and digital person; the other class was the control group, implemented the traditional experimental teaching mode. The teaching effect was evaluated by questionnaire and specimen test. Results Compared with the control group, the students’specimen examination scores were significantly higher in experimental group（P<0.05）;questionnaire survey showed that the students’teaching satisfaction,learning enthusiasm,creativity and exploration spirits were significantly higher in experimental group. Conclusion The teaching mode of the combination of body specimen and digital person can improve students’ examination scores, mobilize learning enthusiasm, stimulate creativity and exploration spirits.