Role of inflammation between pyroptosis and atherosclerosis

WANG Xi-zhi YUAN Jia-ying ZHANG Jian ZHANG Song-ou LIU Xue-hong*

doi:10.16098/j.issn.0529-1356.2019.04.024

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Acta Anatomica Sinica ›› 2019, Vol. 50 ›› Issue (4) : 543-548. DOI: 10.16098/j.issn.0529-1356.2019.04.024

Review

Role of inflammation between pyroptosis and atherosclerosis

WANG Xi-zhi YUAN Jia-ying ZHANG Jian ZHANG Song-ou LIU Xue-hong*

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Abstract

Cardiovascular disease is the highest mortality disease in the world’s chronic noninfectious diseases，and atherosclerosis plays an important role in the development of cardiovascular disease. Inflammation is closely related to the formation of atherosclerosis, and it is widely involved in the process of pyroptosis. The important functional molecules of nucleotide-binding oligomerization domain-like receptor protein 3(NLRP3), apoptosis-associated speck-like protein containing CARD(ASC) and Caspase-1 are involved in the formation of AS. The process of pyroptosis is accompanied by the production and release of interleukin(IL) and other inflammatory mediators, and the inflammatory reaction may in turn promote the development of pyroptosis. Therefore, the three aspects about the role of inflammation in atherosclerosis, pyroptosis, and its function between the two are reviewed in this review.

Key words

Inflammation / Pyroptosis / Atherosclerosis / Signaling pathway / Cardiovascular disease / Human

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WANG Xi-zhi YUAN Jia-ying ZHANG Jian ZHANG Song-ou LIU Xue-hong. Role of inflammation between pyroptosis and atherosclerosis[J]. Acta Anatomica Sinica. 2019, 50(4): 543-548 https://doi.org/10.16098/j.issn.0529-1356.2019.04.024

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