Serum leptin and polymorphism of leptin receptor gene Gln223Arg of Qinghai patients with pregnancy-induced hypertension syndrome

ZHUANG Wen-ting ZHAO De-xiong WANG Xiang-lin LI Hong-rong LI Chang-xing LI Fu-xin KONG De-xia LI Jian-hua*

doi:10.16098/j.issn.0529-1356.2018.06.020

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Acta Anatomica Sinica ›› 2018, Vol. 49 ›› Issue (6) : 814-818. DOI: 10.16098/j.issn.0529-1356.2018.06.020

Serum leptin and polymorphism of leptin receptor gene Gln223Arg of Qinghai patients with pregnancy-induced hypertension syndrome

ZHUANG Wen-ting¹ ZHAO De-xiong² WANG Xiang-lin¹ LI Hong-rong³ LI Chang-xing¹LI Fu-xin¹ KONG De-xia⁴ LI Jian-hua ^1*

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Abstract

Objective To investigate the relationship between polymorphism of leptin receptor(LEPR) gene Gln223Arg (rs1137101) and pregnancyinduced hypertension syndrome. Methods The study consisted of 107 patients of pregnancy-induced hypertension syndrome (PIH) subjects, 116 normal pregnancy subjects were studied to detect their sera level of leptin by ELISA. The LEPR Gln223Arg genotype was detected by polymerase chain reaction fragment length polymorphism (PCR-RFLP). Results The PIH group sera leptin level was higher than control group(P<0.05).The frequences of GG,GA,AA genotype of LEPR Gln223Arg in PIH group were 49.5%,43.9% and 6.5%, in control group were 63.8%,32.8% and 3.4%. There was difference in frequency distribution of LEPR genotype between PIH group and control group. The frequency of A gene in PIH group was higher than the control group（χ²=4.60，P<0.05，OR=0.62，95% CI=0.40-0.96）.Conclusion The A allele of LEPR Gln223Arg might be a genetic marker and a latent risk factor for PIH recurrence.

Key words

Pregnancy-induced hypertension syndrome

/ Leptin / Leptin receptor / Gene polymorphism / Enzyme-linked immunosorbent assay / Human

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ZHUANG Wen-ting ZHAO De-xiong WANG Xiang-lin LI Hong-rong LI Chang-xing LI Fu-xin KONG De-xia LI Jian-hua. Serum leptin and polymorphism of leptin receptor gene Gln223Arg of Qinghai patients with pregnancy-induced hypertension syndrome[J]. Acta Anatomica Sinica. 2018, 49(6): 814-818 https://doi.org/10.16098/j.issn.0529-1356.2018.06.020

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