Transcription and regulation of rDNA in cell development

LI Jia WANG Qi GONG Tian-tian ZHANG Yue SHAN Zhi-yan* LEI Lei

doi:10.16098/j.issn.0529-1356.2018.05.023

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Acta Anatomica Sinica ›› 2018, Vol. 49 ›› Issue (5) : 695-698. DOI: 10.16098/j.issn.0529-1356.2018.05.023

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Transcription and regulation of rDNA in cell development

LI Jia WANG Qi GONG Tian-tian ZHANG Yue SHAN Zhi-yan* LEI Lei

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Abstract

The growth and development of cells are regulated by ribosome DNA(rDNA) and protein gene. Eighty-five percent of the total RNA is the transcription product of rDNA. Changes in rDNA transcription may lead to ribosomal biosynthesis stress, which affects cells growth, proliferation and differentiation, and further leads to the occurrence of diseases. Revealing the mechanism of rDNA transcriptional regulation is helpful to further elucidate the mechanism of cell development and find a new target for the treatment of diseases. In this paper, we describe the structure of rDNA and its transcriptional regulation,and discuss the roles of rDNA on the stem cells and occurring, treatment of disease, which provides a theoretical basis for rDNA in clinical research.

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rDNA / Cell development / Regulation

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LI Jia WANG Qi GONG Tian-tian ZHANG Yue SHAN Zhi-yan LEI Lei. Transcription and regulation of rDNA in cell development[J]. Acta Anatomica Sinica. 2018, 49(5): 695-698 https://doi.org/10.16098/j.issn.0529-1356.2018.05.023

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