Differential analysis of brain structure volume associated with Parkinson’s disease based on nuclear magnetic resonance T1 imaging

LIU Gui-xue SHI Yong-hong* WANG Shi-qing LI Wen-sheng*

doi:10.16098/j.issn.0529-1356.2018.03.013

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Acta Anatomica Sinica ›› 2018, Vol. 49 ›› Issue (3) : 347-354. DOI: 10.16098/j.issn.0529-1356.2018.03.013

Anatomy

Differential analysis of brain structure volume associated with Parkinson’s disease based on nuclear magnetic resonance T1 imaging

LIU Gui-xue^1,3 SHI Yong-hong ^2,3* WANG Shi-qing^2,3 LI Wen-sheng^1,2,3*

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Abstract

Objective To investigate the significance of MRI volume measurement in the morphological changes caused by Parkinson’s disease (PD) and its application in early diagnosis. The volume changes of caudate nucleus, putamen, globus pallidus, midbrain, dorsal thalamus, hippocampus and amygdala in patients with Parkinson’s disease were analyzed based on 3.0T MRI. Methods 3.0T MRI scans were performed in 40 patients with early and intermediate Parkinson’s disease (PD group) and 32 age-matched normal control subjects (NC group), respectively. The total brain, bilateral caudate nucleus, bilateral putamen, bilateral globus pallidus, midbrain, bilateral dorsal thalamus, bilateral hippocampus and bilateral amygdala, were manually delineated by the software of ITK-snap, and their volumes were calculated and normalized respectively. SPSS was used to compare and analyze the differences between the PD group and the NC group. Results There was no difference in the volume of the whole brain between the PD and the NC (P>0.05). There were significant differences in the standardized volume of the bilateral putamen, bilateral globus pallidus, bilateral dorsal thalamus, and midbrain (P<0.05), but there were no differences in the standardized volume of bilateral caudate nucleus, bilateral hippocampus and bilateral amygdale (P>0.05). Conclusion MRI volume measurement of the change of caudate nucleus, putamen, globus pallidus, midbrain, dorsal thalamus, hippocampus and amygdala in patients with PD can be helpful for the diagnosis of Parkinson’s disease.

Key words

Parkinson’s disease

/ Caudate nucleus / Putamen / Globus pallidus / Midbrain / Dorsal thalamus / Hippocampus / Amygdala / Magnetic resonance imaging / Human

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LIU Gui-xue SHI Yong-hong WANG Shi-qing LI Wen-sheng.

Differential analysis of brain structure volume associated with Parkinson’s disease based on nuclear magnetic resonance T1 imaging

[J]. Acta Anatomica Sinica. 2018, 49(3): 347-354 https://doi.org/10.16098/j.issn.0529-1356.2018.03.013

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