Research progress of growth arrest and DNA damage inducible 45&alpha; in liver regeneration and liver diseases

YANG Xian-guang LI Shuai-hong HE Chun-cui XIA Cong ZHU Lin ZHAO Wei-ming XU Cun-shuan*

doi:10.16098/j.issn.0529-1356.2018.02.022

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Acta Anatomica Sinica ›› 2018, Vol. 49 ›› Issue (2) : 268-272. DOI: 10.16098/j.issn.0529-1356.2018.02.022

Review

Research progress of growth arrest and DNA damage inducible 45α in liver regeneration and liver diseases

YANG Xian-guang^{1, 2} LI Shuai-hong¹HE Chun-cui¹ XIA Cong¹ ZHU Lin¹ ZHAO Wei-ming^1,2 XU Cun-shuan ^1,2*

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Abstract

The growth arrest and DNA damage inducible 45 alpha (GADD45α) is a stress-inducible protein. Variety of stress can induce the expression of growth arrest and DNA damage inducible 45alpha(Gadd45α) gene. Gadd45α has been found to be abundantly expressed in various liver diseases, and be closely related to the development and prognosis of liver cancer, liver fibrosis and fatty liver. GADD45α protein plays an important role in regulating cell cycle, maintaining genome stability, and inducing apoptosis by interacting with other proteins. This review summarizes the progress of liver regeneration and GADD45α, and could lay a foundation for further understanding of the mechanism of liver regeneration and liver diseases, and for the treatment and prevention of liver diseases.

Key words

Liver regeneration / Growth arrest and DNA damage inducible 45α / Repair of DNA damage / Cell proliferation

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YANG Xian-guang LI Shuai-hong HE Chun-cui XIA Cong ZHU Lin ZHAO Wei-ming XU Cun-shuan. Research progress of growth arrest and DNA damage inducible 45α in liver regeneration and liver diseases[J]. Acta Anatomica Sinica. 2018, 49(2): 268-272 https://doi.org/10.16098/j.issn.0529-1356.2018.02.022

References

［1］Juza RM, Pauli EM. Clinical and surgical anatomy of the liver: a review for clinicians ［J］. Clin Anat, 2014, 27(5): 764-769.

［2］Frenzel C,Teschke R. Herbal Hepatotoxicity: clinical characteristics and listing compilation ［J］. Inte J Mole Sciences, 2016, 17(5): E588.

［3］Klimczak A, Kozlowska U. Mesenchymal stromal cells and tissue-specific progenitor cells: their role in tissue homeostasis ［J］. Stem Cells Int, 2016, 2016: 4285215.

［4］Wang FS, Fan JG, Zhang Z, et al. The global burden of liver disease: the major impact of China ［J］. Hepatology, 2014, 60(6): 2099-2108.

［5］Jonscher KR, Alfonso-Garcia A, Suhalim JL, et al. Spaceflight Activates Lipotoxic Pathways in Mouse Liver ［J］. PLoS One, 2016, 11(4): E0152877.

［6］Wang P, Petrella F, Nicosia L, et al. Molecular imaging of stem cell transplantation for liver diseases: monitoring, clinical translation, and theranostics ［J］. Stem cells Int, 2016, 2016: 4058656.

［7］Russo FP, Ferrarese A, Zanetto A. Recent advances in understanding and managing liver transplantation ［J］. F1000Research, 2016, 5(F1000 Faculty Rev): 2895.

［8］Tessitore A, Cicciarelli G, Del Vecchio F, et al. MicroRNA expression analysis in high fat diet-induced NAFLD-NASH-HCC progression: study on C57BL/6J mice ［J］. BMC Cancer, 2016, 16(1): 3

［9］Chauhan A, Legewie S, Westermark PO, et al. A mesoscale model of G1/S phase transition in liver regeneration ［J］. J Theor Biol, 2008, 252(3): 465-473.

［10］Espanol-Suner R, Carpentier R, Van Hul N, et al. Liver progenitor cells yield functional hepatocytes in response to chronic liver injury in mice ［J］. Gastroenterology, 2012, 143(6): 1564-1575.

［11］Mao SA, Glorioso JM, Nyberg SL. Liver regeneration ［J］. Transl Res, 2014, 163(4): 352-362.

［12］Xu CS, Zhao WM, Hao YP, et al. Comparative analysis of gene expression profiles of acute hepatic failure and that of liver regeneration in rat ［J］. Gene, 2013, 528(2): 59-66.

［13］Fitz Gerald MJ, Webber EM, Donovan JR. Rapid DNA binding by nuclear factor kappa B in hepatocytes at the start of liver regeneration ［J］. Cell Growth Differ, 1995, 6(4):417-427.

［14］Taub R. Liver regeneration: from myth to mechanism［J］. Nat Revi Mole Cell Biol, 2004, 5(10):836-847.

［15］Cressman DE, Greenbaum LE, DeAngelis RA, et al. Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice ［J］. Science, 1996, 274(5291):1379-1383.

［16］Hayashi H, Nagaki M, Imose M, et al. Normal liver regeneration and liver cell apoptosis after partial hepatectomy in tumor necrosis factor-alpha-deficient mice［J］.Liver Int, 2005, 25(1):162-170.

［17］Johnen H，González-Silva L，Carramolino L，et al．Gadd45g is essential for primary sex determination，male fertility and testis development［J］.PLoS One, 2013, 8(3): e58751.

［18］Schaefer KN, Geil WM, Sweredoski MJ, et al. Oxidation of p53 through DNA charge transport involves a network of disulfides within the DNA-binding domain ［J］. Biochemistry, 2015, 54(3): 932-941.

［19］Vairapandi M, Balliet AG, Hoffman B, et al. GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress ［J］. J Cell Physiol, 2002, 192(3): 327-338.

［20] Bulavin DV, Kovalsky O, Hollander MC, et al. Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of GADD45α［J］. Mol Cell Biol, 2003, 23(11): 3859-3871.

［21］Zerbini LF, Wang Y, Czibere A, et al. NF-kappa B-mediated repression of growth arrest-and DNA-damage-inducible proteins 45alpha and gamma is essential for cancer cell survival ［J］. PNAS USA, 2004, 101(37): 13618-13623.

［22］Gupta SK, Gupta M, Hoffman B, et al. Hematopoietic cells from GADD45α-deficient and gadd45b-deficient mice exhibit impaired stress responses to acute stimulation with cytokines, myeloablation and inflammation ［J］. Oncogene, 2006, 25(40): 5537-5546.

［23］Yang Z, Song L, Huang C. Gadd45 proteins as critical signal transducers linking NF-kappaB to MAPK cascades ［J］. Curr Cancer Drug Targets, 2009, 9(8): 915-930.

［24］Zhang D, Zhang W, Li D, et al. GADD45αinhibits autophagy by regulating the interaction between BECN1 and PIK3C3 ［J］. Autophagy, 2015, 11(12): 2247-2258.

［25］Wang XW, Zhan Q, Coursen JD, et al. GADD45 induction of a G2/M cell cycle checkpoint［J］. PNAS USA, 1999, 96(7):3706-3711.

［26］Jin S, Antinore MJ, Lung FD, et al. The GADD45 inhibition of Cdc2 kinase correlates with GADD45-mediated growth suppression［J］. J Biol Chem, 2000, 275(22):16602-16608.［27］Ramachandran K, Gopisetty G, Gordian E, et al. Methylation-mediated repression of GADD45α in prostate cancer and its role as a potential therapeutic target ［J］. Cancer Res, 2009, 69(4): 1527-1535.

［28］Srivastava AK, Bhatnagar P, Singh M, et al. Synthesis of PLGA nanoparticles of tea polyphenols and their strong in vivo protective effect against chemically induced DNA damage ［J］. Int J Nanomedicine, 2013, 8: 1451-1462.

［29］Chen Y, Ma X, Zhang M, et al. GADD45α regulates hematopoietic stem cell stress responses in mice ［J］. Blood, 2014, 123(6): 851-862.

［30］Zhang W, Hoffman B, Liebermann DA. Ectopic expression of MyD118/Gadd45/CR6 (Gadd45beta/alpha/gamma) sensitizes neoplastic cells to genotoxic stress-induced apoptosis ［J］. Int J Oncol, 2001, 18(4): 749-757.

［31］Wingert S, Thalheimer FB, Haetscher N, et al. DNA-damage response gene GADD45α induces differentiation in hematopoietic stem cells without inhibiting cell cycle or survival ［J］. Stem Cells, 2016, 34(3): 699-710.

［32］Zhan Q, Chen IT, Antinore MJ, et al. Tumor suppressor p53 can participate in transcriptional induction of the GADD45 promoter in the absence of direct DNA binding. ［J］. Mol Cell Biol, 1998, 18 (5):2768-2778.

［33］Fan W, Jin S, Tong T, et al. BRCA1 regulates GADD45 through its interactions with the OCT-1 and CAAT motifs ［J］. Biol Chem,2002,277 (10): 8061-8067.

［34］Yang XG, Zhu L, Zhao WM, et al. Regulatory role of GADD45α in rat liver regeneration［J］.Acta Anatomica Sinica,2016,47(3):323-329.(in Chinese)

杨献光,朱琳,赵卫明,等.GADD45α对大鼠部分肝切除后肝脏再生的调控作用［J］. 解剖学报,2016,47(3):323-329.

［35］Hong L, Sun QF, Xu TY, et al. New role and molecular mechanism of GADD45α in hepatic fibrosis ［J］. World J Gastroenterol, 2016, 22(9): 2779-2788.

［36］Kadar B, Gombos K, Szele E, et al. Effects of isoflurane on NF kappa B p65, GADD45α and JNK1 expression in the vital organs of CBA/CA mice ［J］. In Vivo, 2011, 25(2): 241-244.

［37］Wang J, Che B, Zhang LW, et al. Comparative genotoxicity of silver nanoparticles in human liver HepG2 and lung epithelial A549 cells ［J］. J Appli Toxicol JAT, 2017, 37(4): 495-501.

［38］Chen L, Tian H, Li M, et al. Derivate isocorydine inhibits cell proliferation in hepatocellular carcinoma cell lines by inducing G2/M cell cycle arrest and apoptosis ［J］. Tumour Biol, 2016, 37(5): 5951-5961.

［39］Notas G, Alexaki VI, Kampa M, et al. APRIL binding to BCMA activates a JNK2-FOXO3-GADD45 pathway and induces a G2/M cell growth arrest in liver cells ［J］. J Immunol, 2012, 189(10): 4748-4758.

［40］Gramantieri L, Chieco P, Giovannini C, et al. GADD45-alpha expression in cirrhosis and hepatocellular carcinoma: relationship with DNA repair and proliferation ［J］. Hum Pathol, 2005, 36(11): 1154-1162.

［41］Cheng D, Zhao L, Zhang L, et al. p53 controls hepatitis C virus non-structural protein 5A-mediated down regulation of GADD45alpha expression via the NF-kappa B and PI3K-Akt pathways ［J］. J Gen Virol, 2013, 94(Pt 2): 326-335.