Androgen, androgen receptor and polycystic ovary syndrome

YANG Mei LIN Hai-wei ZHANG Hong-quan XU Xiao-ming* CHEN Xi*

doi:10.16098/j.issn.0529-1356.2018.01.023

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Acta Anatomica Sinica ›› 2018, Vol. 49 ›› Issue (1) : 132-136. DOI: 10.16098/j.issn.0529-1356.2018.01.023

Review

Androgen, androgen receptor and polycystic ovary syndrome

YANG Mei ^1,2 LIN Hai-wei¹ ZHANG Hong-quan² XU Xiao-ming ^1* CHEN Xi ^3*

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Abstract

Polycystic ovary syndrome (PCOS), with a prevalence of 5%-10%, is the most common endocrine and metabolic dysfunction of reproductive age women. However, the underlying mechanism has not been fully elucidated. Hyperandrogenism is the leading defect in PCOS patients, especially local androgen secretion by the ovary is the key element for PCOS pathogenesis. Androgen activates androgen receptor (AR), so the role of AR is an indispensable factor. This review focuses on the functions of androgen and AR in PCOS pathogenesis.

Key words

Androgen / Androgen receptor / Hyperandrogenism / Polycystic ovary syndrome

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YANG Mei LIN Hai-wei ZHANG Hong-quan XU Xiao-ming CHEN Xi. Androgen, androgen receptor and polycystic ovary syndrome[J]. Acta Anatomica Sinica. 2018, 49(1): 132-136 https://doi.org/10.16098/j.issn.0529-1356.2018.01.023

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