Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis

WANG Qiao-zhi FAN Jing ZHANG Wei-guang*

doi:10.16098/j.issn.0529-1356.2017.06.023

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Acta Anatomica Sinica ›› 2017, Vol. 48 ›› Issue (6) : 766-770. DOI: 10.16098/j.issn.0529-1356.2017.06.023

Review

Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis

WANG Qiao-zhi ^1.2 FAN Jing¹ZHANG Wei-guang^1*

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Abstract

Liver sinusoidal endothelial cells (LSECs) are gossamer-thin cells that line the hepatic sinusoid and they are perforated with pores called fenestrations clustered in sieve plates. There is growing evidence that fenestrations may work as a permselective ultrafiltration installation which is important for the hepatic to uptake substrates, particularly metabolism of lipoproteins. Abnormal fenestratel structure had been considered as a vital factor to liver lipid metabolism disorders. This review mainly focused on the relationship between ultrastructure of the fenestration, the fenestrated mechanism, the regulation factor of fenestration, and hepatic steatosis.

Key words

Hepatic steatosis / Liver sinusoidal endothelial cell / Fenestration / Lipid metabolism

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WANG Qiao-zhi FAN Jing ZHANG Wei-guang. Research progress on fenestrated regulation of hepatic sinusoidal endothelial cells and hepatic steatosis[J]. Acta Anatomica Sinica. 2017, 48(6): 766-770 https://doi.org/10.16098/j.issn.0529-1356.2017.06.023

References

［1］Wisse E. An electron microscopic study of the fenestrated endothelial lining of rat liver sinusoids［J］. J Ultrastruct Res, 1970, 31(1):125-150.

［2］Cogger VC, Le CDG. Fenestrations in the liver sinusoidal endothelial cell. In: Arias IM. The Liver: Biology and Pathobiology ［M］. 5th Eds. Newyork: John Wiley & Sons, Ltd, 2009:389-406.

［3］Braet F, Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review ［J］. Comp Hepatol, 2002, 1(1):1-17.

［4］Wisse E, De Zanger RB, Jacobs R,et al. Scanning electron microscope observations on the structure of portal veins, sinusoids and central veins in rat liver ［J］. Scan Electron Microsc, 1983, (Pt 3):1441-1452.

［5］Gantz D, Bennett CS, Derksen A, et al. Size and shape determination of fixed chylomicrons and emulsions with fluid or solid surfaces by three-dimensional analysis of shadows ［J］. J Lipid Res, 1990, 31(1):163-171.

［6］Fraser R, Dobbs BR, Rogers GWT. Lipoproteins and the liver sieve: the role of the fenestrated sinusoidal endothelium in lipoprotein metabolism, atherosclerosis, and cirrhosis ［J］. Hepatology, 1995, 21(3):863-874.

［7］Cogger VC,Hilmer SN, Sullivan D, et al. Hyperlipidemia and surfactants: the liver sieve is a link ［J］. Atherosclerosis, 2006, 189(2):273-281.

［8］Cogger VG, Warren A, Fraser R, et al. Hepatic sinusoidal pseudocapillarization with aging in the non-human primate ［J］. Exp Gerontol, 2003, 38(10):1101-1107.

［9］Enomoto K, Nishikawa Y, Omori Y, et al. Cell biology and pathology of liver sinusoidal endothelial cells［J］. Med Mol Morphol, 2004, 37(4):208-215.

［10］Yokomori H, Oda M, Ogi M, et al. Endothelial nitric oxide synthase and caveolin-1 are colocalized in sinusoidal endothelial fenestrae ［J］. Liver, 2001, 21(3):198-206.

［11］Warren A, Cogger VC, Arias IM, et al. Liver sinusoidal endothelial fenestrations in caveolin-1 knockout mice ［J］. Microcirculation, 2010, 17(1):32-38.

［12］Herrnberger L, Hennig R, Kremer W, et al. Formation of fenestrae in murine liver sinusoids depends on pasmalemma vesicle-associated protein and is required for lipoprotein passage［J］. PLoS One, 2014, 9(12): e115005.

［13］Tazaki T, Sasaki T, Uto K, et al. P130Cas, crk-associated substrate plays essential roles in liver development by regulating sinusoidal endothelial cell fenestration［J］. Hepatology,2010, 52(3):1089-1099.

［14］Braet F, De Zanger R, Baekeland M, et al. Structure and dynamics of the fenestrae-associated cytoskeleton of rat liver sinusoidal endothelial cells ［J］. Hepatology, 1995, 21(1):180-189.

［15］Oda M, Tsukada N, Watanabe N, et al. Heterogeneity of hepatic lobule some ultrastructural aspects of hepatic microcirculation system［J］. J Clin Electron Microscopy, 1983, 6(1):5-6.

［16］Braet F, Spector I, De ZR, et al. A novel structure involved in the formation of liver endothelial cell fenestrae revealed by using the actin inhibitor misakinolide ［J］. Proc Natl AcadSci, 1998, 95(23): 13635-13640.

［17］Yokomori H, Oda M, Ishii H. Endothelin-1 suppresses plasma membrane Ca2+-ATPase, concomitant with contraction of hepatic sinusoidal endothelial fenestrae［J］. Gastroenterology, 2003, 162(2):557-566.

［18］Hanna S, El-Sibai M. Signaling networks of Rho GTPases in cell motility ［J］. Cell Signal, 2013, 25(10):1955-1961.

［19］Eguchi S, Yanaga K, Sugiyama N, et al. Relationship between portal venous flow and liver regeneration in patients after living donor right-lobe liver transplantation［J］. Liver Transpl, 2003, 9(6):547-551.

［20］Yokomori H, Oda M, Ogi M, et al. Endothelial nitric oxide synthase and caveolin-1 are colocalized in sinusoidal endothelial fenestrae ［J］. Liver, 2001, 21(3):198-206.

［21］Schmidt HH, Lohmann SM, Walter U. The nitric oxide and cGMP signal transduction system: regulation and mechanism of action ［J］. Biochim Biophys Acta, 1993, 1178(2):153-175.

［22］Kraft ML. Plasma membrane organization and function: moving past lipid rafts ［J］. Mol Biol Cell, 2011, 24(18):2765-2768.

［23］Funyu J, Mochida S, Inao M, et al. VEGF can act as vascular permeability factor in the hepatic sinusoids through upregulation of porosity of endothelial cells ［J］. Biochem Biophys Res Commun, 2001, 280(2):481-485.

［24］Deleve LD, Wang X, Hu L, et al. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation ［J］. Am J Physiol Gastrointest Liver Physiol, 2004, 287(4):G757-763.

［25］Díaz-Juárez J, Hernández-Mu?oz R. The role of calcium and nitric oxide during liver enzyme release induced by increased physical forces as evidenced in partially hepatectomized rats ［J］. Liver Transpl, 2011, 17(3):334-343.

［26］Ding JM, Chen P, Zhang L, et al. Effects of shear stress on the secretions of sinusoidal endothelial cells ［J］. Chinese Journal of Bases and Clinics in General Surgery, 2005,12(5):455-458. (in Chinese)

丁纪明，陈平，张林，等.切应力对大鼠肝窦内皮细胞分泌功能的影响［J］.中国普外基础与临床杂志, 2005,12(5):455-458.

［27］Morris R, Cox H, Mombelli E, et al. Rafts, little caves and large potholes: how lipid structure interacts with membrane proteins to create functionally diverse membrane environments ［J］. Subcell Biochem, 2004,37:35-118.

［28］Pike LJ. Rafts defined: a report on the keystone symposium on lipid rafts and cell function ［J］. J Lipid Res, 2006, 47(7):1597-1598.

［29］Cogger VC, Mcnerney GP, Nyunt T, et al. Three dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations ［J］. J Struct Biol, 2010, 171(3):382-388.

［30］Svistounov D, Warren A, Mcnerney GP, et al. The relationship between fenestrations, sieve plates and rafts in liver sinusoidal endothelial cells ［J］. PLoS One, 2012, 7(9):e46134.

［31］Heerklotz H. Triton promotes domain formation in lipid raft mixtures ［J］. Biophys J, 2002, 83(5):2693-2701.

［32］Cottalasso D, Bassi AM, Canepa C, et al. Chronic ethanol treatment: dolichol and retinol distribution in isolated rat liver cells ［J］. Free Radic Biol Med, 2003, 34(3):337-344.

［33］Sarphie TG, Deaciuc IV, Spitzer JJ, et al. Liver sinusoid during chronic alcohol consumption in the rat: an electron microscopic study ［J］. Alcohol Clin Exp Res, 1995, 19(2):291-298.

［34］Wang BY, Ju XH, Fu BY, et al. Effects of ethanol on liver sinusoidal endothelial cells-fenestrae of rats ［J］. Hepatobiliary Pancreat Dis Int, 2005, 4(3):422-426.

［35］Zhao S, Zhang Z, Qian L, et al. Tetramethylpyrazine attenuates carbon tetrachloride-caused liver injury and fibrogenesis and reduces hepatic angiogenesis in rats ［J］. Biomed Pharmacother, 2016,86 (2):521-530.

［36］Nakadate K, Motojima K, Tanaka-Nakadate S. Dilatation of sinusoidal capillary and swelling of sinusoidal fenestration in obesity: an ultrastructural study ［J］. Ultrastruct Pathol, 2015, 39(1):30-37.

［37］Miyao M, Kotani H, Ishida T, et al. Pivotal role of liver sinusoidal endothelial cells in NAFLD/NASH progression ［J］. Lab Invest, 2015, 95(10):1130-1144.

［38］Braet F, Wisse E, Bomans P, et al. Contribution of high-resolution correlative imaging techniques in the study of the liver sieve in three-dimensions ［J］. Microsc Res Tech, 2007, 70(3):230-242.

［39］Braet F, Wisse E. AFM imaging of fenestrated liver sinosoidal endothelial cells ［J］. Micron, 2012, 43(12):1252-1258.

［40］Kizilyaprak C, Daraspe J, Humbel BM. Focused ion beam scanning electron microscopy in biology ［J］. J Microsc, 2014, 254(3):109-114.

［41］Carlton PM. Three-dimensional structured illumination microscopy and its application to chromosome structure ［J］. Chromosome Res, 2008, 16(3):351-365.