Structure, functions and relative diseases of synapse-associated protein 102

SU Dong-ning CHANG Li-rong* WU Yan*

doi:10.16098/j.issn.0529-1356.2017.05.023

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Acta Anatomica Sinica ›› 2017, Vol. 48 ›› Issue (5) : 628-632. DOI: 10.16098/j.issn.0529-1356.2017.05.023

Review

Structure, functions and relative diseases of synapse-associated protein 102

SU Dong-ning¹ CHANG Li-rong^2* WU Yan^2*

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Abstract

Synapse-associated protein 102 (SAP102) is a significant scaffold protein in postsynaptic density (PSD) and belongs to membraneassociated guanylate kinases (MAGUKs). It is highly expressed in both neonatal and mature neurons. SAP102 plays an important role in the trafficking of NMDA receptor clusters in the vesicles, anchoring certain receptors and channel proteins on the membrane and regulating development of the synapses in the cortex. Abnormal changes of SAP102 are related to many diseases, such as Alzheimer’s disease and schizophrenia. Although it is crucial for both the normal biology functions of nervous system and the occurrence or development of certain diseases，the study of SAP102 is not enough. In this review, we focus on the structure, functions and relative diseases of SAP102.

Key words

Synapse associated protein 102 / Membrane associated guanylate kinases / N methyl D aspartate receptor / Postsynaptic density

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SU Dong-ning CHANG Li-rong WU Yan. Structure, functions and relative diseases of synapse-associated protein 102[J]. Acta Anatomica Sinica. 2017, 48(5): 628-632 https://doi.org/10.16098/j.issn.0529-1356.2017.05.023

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