Expressions and their significance of mast cell tryptase and mast cell chymase in premenopausal and postmenopausal endometrial polyps

Cui-jing ZHAI Hong-kai ZHANG Wei-dong CHEN Cui-zhi WANG Dong-mei ZHANG

doi:10.16098/j.issn.0529-1356.2017.04.017

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Acta Anatomica Sinica ›› 2017, Vol. 48 ›› Issue (4) : 466-470. DOI: 10.16098/j.issn.0529-1356.2017.04.017

Histology,Embryology and Developmental Biology

Expressions and their significance of mast cell tryptase and mast cell chymase in premenopausal and postmenopausal endometrial polyps

Cui-jing ZHAIHong-kai ZHANG²,Wei-dong CHEN²,Cui-zhi WANG²,Dong-mei ZHANG²

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Abstract

Objective To evaluate the expressions and their significance of mast cell tryptase (MCT) and mast cell chymase (MCC) in endometrial polyps(EPs) of premenopausal and postmenopausal women. Methods The tissue specimens collected from 120 patients were divided into 4 groups: premenopausal EP group(n=35), postmenopausal EP group(n=35), normal proliferative endometrium group(n=25) and normal atrophic endometrium group(n=25). The number of MCT and MCC positive mast cells (MCs) were detected by MaxVision^TM/HRP immunohistochemistrymethod . Results The number of MCT and MCC positive MCs in EP group and normal endometrium group of premenopausal and postmenopausal phase were （11.82 ± 5.24）/high power(HP) and （2.94±2.20）/HP, （4.18 ± 2.32）/HP and （2.18±1.52）/HP, （2.19 ± 1.80）/HP and（0.49±0.60）/HP,（0.35 ± 0.32）/HP and（0.19±0.26）/HP, respectively. Compared with normal endometrium group in the same period, the number of MCT and MCC positive MCs in either premenopausal EP group or postmenopausal EP group were significantly higher (P＜0.05). In EP group, the number of MCT positive MCs in premenopausal women were higher than that in postmenopausal women(P＜0.05). There was no significant difference on the number of MCC positive MCs between preand postmenopausal women(P＞0.05). In endometrial group, the number of MCT and MCC positive MCs in premenopausal women were higher than that in postmenopausal women(P＜0.05). Conclusion Overactivity of MCs in endometrum, resulting in endometrial inflammatory lesions, may be an inducement of EPs formation and development in endometrium.

Key words

Mast cell tryptase / Mast cell chymase / Endometrial polyp / Immunohistochemistry / Human

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Cui-jing ZHAI Hong-kai ZHANG Wei-dong CHEN Cui-zhi WANG Dong-mei ZHANG. Expressions and their significance of mast cell tryptase and mast cell chymase in premenopausal and postmenopausal endometrial polyps[J]. Acta Anatomica Sinica. 2017, 48(4): 466-470 https://doi.org/10.16098/j.issn.0529-1356.2017.04.017

References

［1］Yamakov K. Endometrial polyps-clinico pathological features of malignancy and therapeutic attitude ［J］. Akush Ginekol (Sofiia)，2016，55（1）：59-62.

［2］Lubián López DM，Orihuela López F，García-Berbel Molina L，et al. Endometrial polyps in obese asymptomatic pre and postmenopausal patients with breast cancer: is screening necessary ［J］ ? Gynecol Oncol，2014，133（1）：56-62.

［3］van Hanegem N，Prins MM，Bongers MY，et al. The accuracy of endometrial sampling in women with postmenopausal bleeding: a systematic review and meta-analysis［J］.Eur J Obstet Gynecol Reprod Biol，2016，197：147-155.

［4］Antunes A Jr，Vassallo J，Pinheiro A，et al. Immunohistochemical expression of estrogen and progesterone receptors in endometrial polyps: a comparison between benign and malignant polyps in postmenopausal patients［J］. Oncol Lett，2014，7（6）：1944-1950.

［5］Orii A，Mori A，Zhai YL，et al. Mast cells in smooth muscle tumors of the uterus［J］. Int J Gynecol Pathol，1998，17（4）：336-342.

［6］El-Hamarneh T，Hey-Cunningham AJ，Berbic M，et al. Cellular immune environment in endometrial polyps［J］. Fertil Steril，2013，100（5）：1364-1372.

［7] Al-Jefout M，Black K，Schulke L，et al. Novel finding of high density of activated mast cells in endometrial polyps［J］. Fertil Steril，2009，92（3）：1104-1106.

［8］Zaitsu M，Narita S，Lambert KC，et al. Estradiol activates mast cells via a non-genomic estrogen receptor-alpha and calcium influx［J］. Mol Immunol，2007，44（8）：1977-1985.

［9］Jensen F，Woudwyk M，Teles A，et al. Estradiol and progesterone regulate the migration of mast cells from the periphery to the uterus and induce their maturation and degranulation［J］. PLoS One，2010，5（12）： e14409.

［10］Belot MP，Abdennebi-Najar L，Gaudin F，et al. Progesterone reduces the migration of mast cells toward the chemokine stromal cell-derived factor-1/CXCL12 with an accompanying decrease in CXCR4 receptors［J］. Am J Physiol Endocrinol Metab，2007，292（5）：1410-1417.

［11］Gao CX，Fan ZhJ. The expression of ER、PR and MMP-9 in postmenopausal endometrial polyps［J］. Guide of China Medicine，2015，13（34）：33-35.（in Chinese）

高翠娴，范治军。ER、PR、MMP-9在绝经后子宫内膜息肉中的表达［J］.中国医药指南，2015，13（34）：33-35.

［12］Guidolin D，Marinaccio C，Tortorella C，et al. Nonrandom spatial relationships between mast cells and microvessels in human endometrial carcinoma［J］. Clin Exp Med， 2017，17（1）：71-77.