Association between G894T polymorphism of endothelial nitric oxide gene and pregnancyinduced hypertension syndrome in Han group of Qinghai

LI Hong-rong LI Changp-xing WANG Xiang-lin ZHUANG Wen-ting YAN Shuai LI Jian-hua*

doi:10.16098/j.issn.0529-1356.2017.03.018

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Acta Anatomica Sinica ›› 2017, Vol. 48 ›› Issue (3) : 353-357. DOI: 10.16098/j.issn.0529-1356.2017.03.018

Association between G894T polymorphism of endothelial nitric oxide gene and pregnancyinduced hypertension syndrome in Han group of Qinghai

LI Hong-rong LI Changp-xing WANG Xiang-lin ZHUANG Wen-ting YAN Shuai LI Jian-hua*

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Abstract

Objective To investigate the association between the gene polymorphism of endothelial nitric oxide synthase (eNOS) and pregnancy-induced hypertension syndrome (PIH) in Han population of Qing hai. Methods eNOS genotype with polymerase chain reaction-restriction fragment length polymorphism was performed in 138 PIH subjects and 135 normal pregnancy subjects. The mutation was confirmed by DNA sequencing. Results The frequencies of eNOS GG, GT and TT genotypes were 17.4 %, 82.6 %,0 in PIH group and 0 %, 95.6 %,4.4 % in control Group.There were differences between the two groups of genotype frequency distribution (P<0.05). The frequencies of the two alleles G and T were 58.7 %, 41.3 % in PIH group and 47.8 %, 52.2 % in control group,respectively(P<0.05).The frequency of G gene in PIH group was higher than the control group. Conclusion The study suggests an association between the G894T polymorphism of eNOS gene and PIH in Han group of Qinghai.G allele may be a susceptible gene to PIH（OR=1.229,95%CI: 1.048～1.441）and T allele may be a protective gene to PIH. Pregnant women with GG genotype may be a high susceptible group of pregnancy induced hypertension in Qinghai province.

Key words

Pregnancy-induced hypertension syndrom

/ Polymorphism / Endothelial nitric oxide synthase / Restriction fragment length polymorphism polymerase chain reaction / Pregnant woman

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LI Hong-rong LI Changp-xing WANG Xiang-lin ZHUANG Wen-ting YAN Shuai LI Jian-hua. Association between G894T polymorphism of endothelial nitric oxide gene and pregnancyinduced hypertension syndrome in Han group of Qinghai[J]. Acta Anatomica Sinica. 2017, 48(3): 353-357 https://doi.org/10.16098/j.issn.0529-1356.2017.03.018

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