Polarization and functional regulation of macrophage

GONG Tian-tian HUANG Shao-gang ZHANG Yue LI Jia LEI Lei SHAN Zhi-yan*

doi:10.16098/j.issn.0529-1356.2017.01.019

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Acta Anatomica Sinica ›› 2017, Vol. 48 ›› Issue (1) : 106-110. DOI: 10.16098/j.issn.0529-1356.2017.01.019

Review

Polarization and functional regulation of macrophage

GONG Tian-tian HUANG Shao-gang ZHANG Yue LI Jia LEI Lei SHAN Zhi-yan*

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Abstract

Macrophages have the great plasticity in various tissues in vivo, which play important roles in the development and homeostasis. In response to certain inductors, macrophages can change their phenotype and result in polarization. Polarized macrophages can react to the immune response and participate in tissue repair and remodeling, which have the significant clinic application value. In this review, the classification, regulation mechanism and reprogramming of polarization are addressed, which may provide a theory basis for research of macrophage polarization.

Key words

Macrophage / Polarization / Regulation

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GONG Tian-tian HUANG Shao-gang ZHANG Yue LI Jia LEI Lei SHAN Zhi-yan. Polarization and functional regulation of macrophage[J]. Acta Anatomica Sinica. 2017, 48(1): 106-110 https://doi.org/10.16098/j.issn.0529-1356.2017.01.019

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