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Relationship between androgen receptor CAG/GGN repeat polymorphisms and the ratio of 2D∶4D
ZHANG Chuan LU Hong HAO Sheng-ju YAN You-sheng DANG Jie ZHENG Lei ZHANG Qing-hua HUO Zheng-hao*
Acta Anatomica Sinica ›› 2016 ›› Issue (3) : 409-414.
Relationship between androgen receptor CAG/GGN repeat polymorphisms and the ratio of 2D∶4D
Objective The ratio of the length of the second finger to the fourth finger (2D∶4D) in humans is considered as a putative marker of prenatal exposure to androgen. Some studies have reported the relationship between CAG number and the ratio of 2D∶4D, but their results were variable. Here, we investigated the effect of CAG/GGN repeat polymorphisms in androgen receptor（AR）on 2D∶4D in Chinese people, and we wanted to investigate a suitable statistical method to find the real relationship between AR CAG/GGN repeat polymorphisms and the 2D∶4D ratio. Methods We examined 294 males and 391 females. The CAG and GGN repeats of the AR gene were analyzed on ABI 3730 DNA analyzer, using Peak Scanner software V1.0 to ascertain the size of AR alleles. The 2D∶4D ratio was standardized by x ±2s. We used the quartile method to choose the lower (Q1) and higher (Q3) 2D∶4D ratio. Pearson’s product moment correlation coefficients were used to find the relationship between AR CAG/GGN repeat polymorphisms and the 2D∶4D ratio. Results Females showed significantly higher 2D∶4D ratio than males in the right, and mean 2D∶4D ratio of both hards but not in the DR-L 2D∶4D ratio. There was no relationship between AR CAG/GGN alleles and right、left 2D∶4D of males (P>0.05)，but CAG alleles were positively related to Q1 DR-L, Q3 Mean 2D∶4D ratio of males (r=0.280,P＜0.05,r=0.274,P＜0.05). The shorter CAG alleles were positively related to Q3 Mean 2D∶4D ratio of females (r=0.337,P＜0.05)，the longer CAG alleles were positively related to Q3 right hand and DR-L 2D∶4D ratio of females (r=0.238,P＜0.05;r=0.175, P＜0.05)，the Mean CAG alleles were positively related to Q3 Mean 2D∶4D ratio of females (r=0.236, P P＜0.05), the longer GGN alleles were positively related to Q1 right hand 2D∶4D ratio of females (r=0.204, P＜0.05)，the Mean GGN alleles were positively related to Q3 Mean 2D∶4D ratio of females (r=0.225, P＜0.05). The longer CAG alleles were positively related to right hand 2D∶4D ratio of females. The longer GGN alleles were positively related to right hand 2D∶4D ratio of females. Conclusion 2D∶4D ratio may be used as a simple proxy for AR variation. Combine using the quartile method and Pearson’s product moment correlation coefficients may be a better way to find the relationship between AR variation and 2D∶4D.
［1］Manning JT, Scutt D, Wilson J, et al. The ratio of 2nd to 4th digit length: A predictor of sperm numbers and concentrations of testosterone, luteinizing hormone and oestrogen［J］. Hum Reprod, 1998, 13(11): 3000-3004.
［2］Malas MA, Dogan S, Evcil EH, et al. Fetal development of the hand, digits and digit ratio (2D∶4D)［J］. Early Hum Dev, 2006, 82(7): 469-475.
［3］Galis F, Ten Broek CM, Van Dongen S, et al. Sexual dimorphism in the prenatal digit ratio (2D∶4D)［J］. Arch Sex Behav, 2010, 39(1): 57-62.
［4］Ventura T, Gomes MC, Pita A, et al. Digit ratio (2D∶4D) in newborns: influences of prenatal testosterone and maternal environment［J］. Early Hum Dev, 2013, 89(2): 107-112.
［5］Garn SM, Burdi AR, Babler WJ, et al. Early prenatal attainment of adult metacarpal-phalangeal rankings and proportions［J］. Am J Phys Anthropol, 1975, 43(3): 327-332.
［6］McIntyre M, Ellison PT, Lieberman D, et al. The development of sex differences in digital formula from infancy in the Fels longitudinal study［J］. Proc R Soc B, 2005, 272(1571): 1473-1479.
［7］McIntyre MH, Cohn BA, Ellison PT. Sex dimorphism in digital formulae of children［J］. Am J Phys Anthropol, 2006, 129(1): 143-150.
［8］Trivers R, Manning J, Jacobson A. A longitudinal study of digit ratio (2D∶4D) and other finger ratios in Jamaican children［J］. Horm Behav, 2006, 49(2): 150-156.
［9］Manning JT. Digit Ratio: A Pointer to Fertility, Behavior, and Health［M］. New Jersey：Rutgers University Press, 2002:173.
［10］Bang AK, Carlsen E, Holm M, et al. A study of finger lengths, semen quality and sex hormones in 360 young men from the general Danish population［J］. Hum Reprod, 2005, 20(11): 3109-3113.
［11］Manning JT, Baron-Cohen S, Wheelwright S, et al. The 2nd to 4th digit ratio and autism［J］. Dev Med Child Neurol, 2001, 43(3): 160 -164.
［12］Manning JT, Bundred PE. The ratio of 2nd to 4th digit length: a new predictor of disease predisposition［J］? Med Hypotheses, 2000, 54(5): 855-857.
［13］H?nekopp J, Manning JT, Müller C. Digit ratio (2D∶4D) and physical fitness in males and females: Evidence for effects of prenatal androgens on sexually selected traits［J］. Horm Behav, 2006, 49(4): 545-549.
［14］Collaer ML, Reimers S, Manning JT. Visuospatial performance on an internet line judgment task and potential hormonal markers: sex, sexual orientation, and 2D∶4D［J］. Arch Sex Behav, 2007, 36(2):177-192.
［15］Xiaoqian JC, Lucia FJ. Digit ratio predicts sense of direction in women［J］. PLoS One, 2012, 7(2): e32816.
［16］Lu H, Huo ZhH, Shi ZhY, et al. Fluctuating asymmetry of digit length in breast cancer patients［J］. Acta Anatomica Sinica, 2013, 44(1): 140-143.（in Chinese）
陆宏, 霍正浩, 师志云,等. 乳腺癌患者指长波动性不对称［J］. 解剖学报, 2013, 44(1): 140-143.
［17］Manning JT, Robinson SJ. 2nd to 4th digit ratio and a universal mean for prenatal testosterone in homosexual men［J］. Med Hypotheses, 2003, 61(2): 303306.
［18］Lu H, Huo ZhH, Zhang KJ, et al. Relationship between digit ratio and coronary heart disease［J］. Acta Anatomica Sinica, 2008, 39(5): 765-768.（in Chinese）
陆宏, 霍正浩, 张科静, 等. 指长比与冠心病的相关性研究［J］. 解剖学报, 2008, 39(5): 765-768.
［19］Stevenson JC, Everson PM, Williams DC, et al. Attention deficit/ hyperactivity disorder (ADHD) symptoms and digit ratios in a college sample［J］. Am J Hum Biol, 2007, 19(1): 41-50.
［20］Matchock RL. Low digit ratio (2D∶4D) is associated with delayed menarche［J］. Am J Hum Biol, 2008, 20(4): 487-489.
［21］Talarovicˇová A, Kr?ková L, Blazeková J. Testosterone enhancement during pregnancy influences the 2D∶4D ratio and open field motor activity of rat siblings in adulthood［J］. Horm Behav, 2009, 55(1):235-239.
［22］Zheng Z, Cohn MJ. Developmental basis of sexually dimorphic digit ratios［J］. Proc Natl Acad Sci USA, 2011, 108(39):16289-16294.
［23］Lee DK, Chang C. Endocrine mechanisms of disease: Expression and degradation of androgen receptor: mechanism and clinical implication［J］.J Clin Endocrinol Metab, 2003, 88(9): 4043-4054.
［24］Ding D, Xu L, Menon M, et al. Effect of GGC (glycine) repeat length polymorphism in the human androgen receptor on androgen action［J］. Prostate, 2005, 62(2):133-139.
［25］Manning JT, Bundred PE, Flanagan BF. The ratio of 2nd to 4th digit length: a proxy for transactivation activity of the androgen receptor gene［J］? Med Hypotheses, 2002, 59(3): 334-336.
［26］Manning JT, Bundredb PE, Newtonc DJ, et al. The second to fourth digit ratio and variation in the androgen receptor gene［J］. Evol Hum Behav, 2003, 24(6): 399-405.
［27］Hurd PL, Vaillancourt KL, Dinsdale NL. Aggression, digit ratio and variation in androgen receptor and monoamine oxidase a genes in men［J］. Behav Genet, 2011, 41(4): 543-556.
［28］Butovskaya ML, Vasilyev VA, Lazebny OE, et al. Aggression, Digit ratio, and variation in the androgen receptor,serotonin transporter, and dopamine d4 receptor genes in african foragers: the Hadza［J］. Behav Genet, 2012, 42(4): 647-662.
［29］Loehlin JC, Medland SE, Martin NG. Is CAG sequence length in the androgen receptor gene correlated with finger-length ratio［J］? Personality and Individual Differences, 2012, 52(2): 224-227.
［30］Knickmeyer RC, Woolson S, Hamer RM, et al. 2D∶4D ratios in the first 2 years of life: Stability and relation to testosterone exposure and sensitivity［J］. Horm Behav, 2011, 60(3): 256-263.
［31］Folland JP, Mc CTM, Phypers C, et al. Relationship of 2D∶4D finger ratio with muscle strength, testosterone, and androgen receptor CAG repeat genotype［J］. Am J Phys Anthropol, 2011, 148(1): 81-87.
［32］H?nekopp. No evidence that 2D∶4D is related to the number of CAG repeats in the androgen receptor gene［J］. Front Endocrinol (Lausanne), 2013, 4:185.
［33］Forstmeier W, Mueller JC, Kempenaers B. A polymorphism in the oestrogen receptor gene explains covariance between digit ratio and mating behaviour［J］. Proc Biol Sci, 2010, 277(1698):3353-3361.
［34］McIntyre MH. The use of digit ratios as markers for perinatal androgen action［J］. Reprod Biol Endocrinol, 2006, 4:10.
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