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Retinal regeneration in Zebrafish
ZHANG Shu-qiang LIU Dong XU Hui*
Acta Anatomica Sinica ›› 2015, Vol. 46 ›› Issue (5) : 715-719.
Retinal regeneration in Zebrafish
After retinal injury or disease, mammals exhibit very limited capacity to repair a damaged retina. In contrast, teleost fish such asZebrafishmount a robust regenerative response that recovers all types of lost neurons and glia and restores visual function. The source of cells responsible for this regeneration has been identified as Müller glia. Recent studies have revealed many important signaling and molecular mechanisms regulating Müller glia dedifferentiation and proliferation. In this review, we summarize the history of retinal regeneration research, models of injury, source of cells for regeneration, and its underlying molecular mechanisms.
Retina / Regeneration / Dedifferentiation / Müller glia / Zebrafish
[1]Lamba D, Karl M, Reh T. Neural regeneration and cell replacement: a view from the eye[J]. Cell Stem Cell, 2008, 2(6): 538-549.
[2]Bernardos RL, Barthel LK, Meyers JR, et al. Late-stage neuronal progenitors in the retina are radial Muller glia that function as retinal stem cells [J]. J Neurosci, 2007, 27(26):7028-7040.
[3]Ramachandran R, Reifler A, Parent JM, et al. Conditional gene expression and lineage tracing of tuba1a expressing cells during zebrafish development and retina regeneration[J]. J Comp Neurol, 2010, 518(20): 4196-4212.
[4]Lenkowski JR, Raymond PA. Muller glia: stem cells for generation and regeneration of retinal neurons in teleost fish[J]. Prog Retin Eye Res, 2014, 40: 94-123.
[5]Hitchcock PF, Lindsey Myhr KJ, Easterm SS Jr, et al. Local regeneration in the retina of the goldfish[J]. J Neurobiol, 1992, 23(2): 187-203.
[6]Hitchcock PF, Vanderyt JT. Regeneration of the dopamine-cell mosaic in the retina of the goldfish[J]. Vis Neurosci, 1994, 11(2):209-217.
[7]Cameron DA. Cellular proliferation and neurogenesis in the injured retina of adult zebrafish[J]. Vis Neurosci, 2000, 17(5):789-797.
[8]Goldman D, Hankin M, Li Z, et al. Transgenic zebrafish for studying nervous system development and regeneration[J]. Transgenic Res, 2001, 10(1): 21-33.
[9]Liu Q, Londraville RL, Azodi E, et al. Up-regulation of cadherin-2 and cadherin-4 in regenerating visual structures of adult zebrafish[J]. Exp Neurol, 2002, 177(2): 396-406.
[10]Faillace MP, Julian D, Korenbrot JI. Mitotic activation of proliferative cells in the inner nuclear layer of the mature fish retina: regulatory signals and molecular markers[J]. J Comp Neurol, 2002, 451(2): 127-141.
[11]Hitchcock PF, Cirenza P. Synaptic organization of regenerated retina in the goldfish[J]. J Comp Neurol, 1994, 343(4): 609-616.
[12]Maier W, Wolburg H. Regeneration of the goldfish retina after exposure to different doses of ouabain[J]. Cell Tissue Res, 1979, 202(1): 99-118.
[13]Raymond PA, Reifler MJ, Rivlin PK. Regeneration of goldfish retina: rod precursors are a likely source of regenerated cells[J]. J Neurobiol, 1988, 19(5): 431-463.
[14]Fimbel SM, Montgomery JE, Burket CT, et al. Regeneration of inner retinal neurons after intravitreal injection of ouabain in zebrafish[J]. J Neurosci, 2007, 27(7): 1712-1724.[15]Nagashima M, Barthel LK, Raymond PA. A self-renewing division of zebrafish Muller glial cells generates neuronal progenitors that require N-cadherin to regenerate retinal neurons[J]. Development, 2013, 140(22): 4510-4521.
[16]Fausett BV, Goldman D. A role for alpha1 tubulin-expressing Muller glia in regeneration of the injured zebrafish retina[J]. J Neurosci, 2006, 26(23): 6303-6313.
[17]Thummel R, Kassen SC, Enright JM, et al. Characterization of Muller glia and neuronal progenitors during adult zebrafish retinal regeneration[J]. Exp Eye Res, 2008, 87(5): 433-444.
[18]Lindsey AE, Powers MK. Visual behavior of adult goldfish with regenerating retina[J]. Vis Neurosci, 2007, 24(3): 247-255.
[19]Mensinger AF, Powers MK. Visual function in regenerating teleost retina following cytotoxic lesioning[J]. Vis Neurosci, 1999, 16(2): 241-251.
[20]Sherpa T, Fimbel SM, Mallory DE, et al. Ganglion cell regeneration following whole-retina destruction in zebrafish[J]. Dev Neurobiol, 2008, 68(2): 166-181.
[21]Marc RE, Sperling HG. The chromatic organization of the goldfish cone mosaic[J]. Vision Res, 1976, 16(11): 1211-1224.
[22]Cameron DA, Cornwall MC, MacNichol EF, et al. Visual pigment assignments in regenerated retina[J]. J Neurosci, 1997, 17(3): 917-923.
[23]Stenkamp DL, Powers MK, Carney LH, et al. Evidence for two distinct mechanisms of neurogenesis and cellular pattern formation in regenerated goldfish retinas[J]. J Comp Neurol, 2001, 431(4): 363-381.
[24]Raymond PA, Barthel LK, Bernardos RL, et al. Molecular characterization of retinal stem cells and their niches in adult zebrafish[J]. BMC Dev Biol, 2006, 6:-36.
[25]Thummel R, Enright JM, Kassen SC, et al. Pax6a and Pax6b are required at different points in neuronal progenitor cell proliferation during zebrafish photoreceptor regeneration[J]. Exp Eye Res, 2010, 90(5): 572-582.
[26]Powell C, Grant AR, Cornblath E, et al. Analysis of DNA methylation reveals a partial reprogramming of the Muller glia genome during retina regeneration[J]. Proc Natl Acad Sci USA, 2013, 110(49): 19814-19819.
[27]Ramachandran R, Reifler A, Wan J, et al. Application of Cre-loxP recombination for lineage tracing of adult zebrafish retinal stem cells[J]. Methods Mol Biol, 2012, 884: 129-140.
[28]Bringmann A, Iandiev I, Pannicke T, et al. Cellular signaling and factors involved in Muller cell gliosis: neuroprotective and detrimental effects[J]. Prog Retin Eye Res, 2009, 28(6): 423-451.
[29]Nelson CM, Ackerman KM, O’Hayer P, et al. Tumor necrosis factoralpha is produced by dying retinal neurons and is required for Muller glia proliferation during zebrafish retinal regeneration[J]. J Neurosci, 2013, 33(15): 6524-6539.
[30]Close JL, Liu J, Gumuscu B, et al. Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina[J]. Glia, 2006, 54(2): 94-104.
[31]Fischer AJ, Bongini R. Turning Müller glia into neural progenitors in the retina[J]. Mol Neurobiol, 2010, 42(3): 199-209.
[32]Karl MO, Hayes S, Nelson BR, et al. Stimulation of neural regeneration in the mouse retina[J]. Proc Natl Acad Sci USA, 2008, 105(49): 19508-19513.
[33]Wan J, Ramachandran R, Goldman D. HB-EGF is necessary and sufficient for Müller glia dedifferentiation and retina regeneration[J]. Dev Cell, 2012, 22(2): 334-347.
[34]Hochmann S, Kaslin J, Hans S, et al. Fgf signaling is required for photoreceptor maintenance in the adult zebrafish retina[J]. PLoS One, 2012, 7(1): e30365.
[35]Qin Z, Kidd AR 3rd, Thomas JL, et al. FGF signaling regulates rod photoreceptor cell maintenance and regeneration in zebrafish[J]. Exp Eye Res, 2011, 93(5): 726-734.
[36]Bonni A, Sun Y, Nadal-Vicens M, et al. Regulation of gliogenesis in the central nervous system by the JAK-STAT signaling pathway [J]. Science, 1997, 278(5337):477-483.
[37]Zhang C, Li H, Liu MG, et al. STAT3 activation protects retinal ganglion cell layer neurons in response to stress[J]. Exp Eye Res, 2008, 86(6): 991-997.
[38]Niwa H, Burdon T, Chambers I, et al. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3[J]. Genes Dev, 1998, 12(13): 2048-2060.
[39]Zhao XF, Wan J, Powell C, et al. Leptin and IL-6 family cytokines synergize to stimulate Muller glia reprogramming and retina regeneration[J]. Cell Rep, 2014, 9(1): 272-284.[40]Fausett BV, Gumerson JD, Goldman D. The proneural basic helix-loop-helix gene ascl1a is required for retina regeneration[J]. J Neurosci, 2008, 28(5): 1109-1117.
[41]Ramachandran R, Fausett BV, Goldman D. Ascl1a regulates Muller glia dedifferentiation and retinal regeneration through a Lin-28-dependent, let-7 microRNA signalling pathway[J]. Nat Cell Biol, 2010, 12(11): 1101-1107.
[42]Ramachandran R, Zhao XF, Goldman D. Ascl1a/Dkk/beta-catenin signaling pathway is necessary and glycogen synthase kinase-3beta inhibition is sufficient for zebrafish retina regeneration[J]. Proc Natl Acad Sci USA, 2011, 108(38): 15858-15863.
[43]Pollak J, Wilken MS, Ueki Y, et al. ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors[J]. Development, 2013, 140(12): 2619-2631.
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