Welcome to visit Acta Anatomica Sinica! Today is
Chinese
Transplantation studies of induced pluripotent stem cells at different differentiated stages
LI Jun DU Xiao WU Yan-shuang LEI Lei*
Acta Anatomica Sinica ›› 2015, Vol. 46 ›› Issue (5) : 699-703.
Transplantation studies of induced pluripotent stem cells at different differentiated stages
Induced pluripotent stem cells (iPSCs) which derived from reprogrammed somatic cells, are totipotential cells similar to embryonic stem cells. Recently, iPSCs technology has been promptly improved in methods of induction and in vitro differentiation. Consequently, iPSCs at different differentiated stages have been widely studied in cell transplantation experiments. Here, we summarize the current studies of iPSCs transplantation, and reviewe some novel methods comparing with the older one. We propose that some problems need to be resolved before iPSCs could be applied in clinic therapy.
induced pluripotent Induced pluripotent stem cell / Blastocyst complementation / Organ bud
［1］Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors［J］. Cell, 2006, 126(4): 663-676.
［2］Feng B, Jiang J, Kraus P, et al. Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb［J］. Nat Cell Biol, 2009, 11(2): 197-203.
［3］Gao Y, Chen J, Li K, et al. Replacement of Oct4 by Tet1 during iPSC induction reveals an important role of DNA methylation and hydroxymethylation in reprogramming［J］. Cell Stem Cell, 2013, 12(4): 453-469.
［4］Wernig M, Meissner A, Cassady JP, et al. c-Myc is dispensable for direct reprogramming of mouse fibroblasts［J］. Cell Stem Cell, 2008, 2(1): 10-12.
［5］Kim JB, Sebastiano V, Wu G, et al. Oct4-induced pluripotency in adult neural stem cells［J］. Cell, 2009, 136(3): 411-419.
［6］Takahashi K, Tanabe K, Ohnuki M, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors［J］. Cell, 2007, 131(5): 861-872.
［7］Nelson TJ, MartinezFernandez A, Yamada S, et al. Repair of acute myocardial infarction by human stemness factors induced pluripotent stem cells［J］. Circulation, 2009, 120(5): 408-416.
［8］Zhou Y, Wang S, Yu Z, et al. Induced pluripotent stem cell transplantation in the treatment of porcine chronic myocardial ischemia［J］. Ann Thorac Surg, 2014, 98(6): 2130-2137.
［9］Fink KD, Rossignol J, Lu M, et al. Survival and differentiation of adenovirus-generated induced pluripotent stem cells transplanted into the rat striatum［J］. Cell Transplant, 2014, 23(11): 1407-1423.
［10］Liu H, Kim Y, Sharkis S, et al. In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins［J］. Sci Transl Med, 2011, 3(82): 82ra39.
［11］Sun N, Panetta NJ, Gupta DM, et al. Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci USA, 2009 106(37): 15720-15725.
［12］Chen J, Lansford R, Stewart V, et al. RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development［J］. Proc Natl Acad Sci USA, 1993, 90(10): 4528-4532.
［13］Kobayashi T, Yamaguchi T, Hamanaka S, et al. Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells［J］. Cell, 2010, 142(5): 787-799.
［14］Matsunari H, Nagashima H, Watanabe M, et al. Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs［J］. Proc Natl Acad Sci USA, 2013, 110(12): 4557-4562.
［15］Lutz AJ, Li Ping, Estrada JL, et al. Double knockout pigs deficient in N-glycolylneuraminic acid and Galactose α-1,3-Galactose reduce the humoral barrier to xenotransplantation［J］. Xenotransplantation, 2013, 20(1): 27-35.
［16］Bellin MD, Barton FB, Heitman A, et al. Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes［J］. Am J Transplant, 2012, 12(6): 1576-1583.
［17］Hrvatin S, O’Donnell CW, Deng F, et al. Differentiated human stem cells resemble fetal, not adult, beta cells［J］. Proc Natl Acad Sci USA, 2014, 111(8): 3038-3043.
［18］Pagliuca FW, Millman JR, Gurtler M, et al. Generation of functional human pancreatic beta cells in vitro［J］. Cell, 2014, 159(2): 428-439.
［19］Si-Tayeb K, Noto FK, Nagaoka M, et al. Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells［J］. Hepatology, 2010, 51(1): 297-305.
［20］Wernig M, Zhao JP, Pruszak J, et al. Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson’s disease［J］. Proc Natl Acad Sci USA, 2008, 105(15): 5856-5861.
［21］Hanna J, Wernig M, Markoulaki S, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin［J］. Science, 2007, 318(5858): 1920-1923.
［22］Takebe T, Sekine K, Enomura M, et al. Vascularized and functional human liver from an iPSC-derived organ bud transplant［J］. Nature, 2013, 499(7459): 481-484.
［23］Huang SX, Islam MN, O’Neill J, et al. Efficient generation of lung and airway epithelial cells from human pluripotent stem cells［J］. Nat Biotechnol, 2014, 32(1): 84-91.
［24］Takasato M, Er PX, Becroft M, et al. Directing human embryonic stem cell differentiation towards a renal lineage generates a selforganizing kidney［J］. Nat Cell Biol, 2014, 16(1): 118-126.
［25］McCracken KW, Cata EM, Crawford CM, et al. Modelling human development and disease in pluripotent stem-cell-derived gastric organoids［J］. Nature, 2014, 516(7531): 400-404.
［26］Zhao T, Zhang ZN, Rong Z, et al. Immunogenicity of induced pluripotent stem cells［J］. Nature, 2011, 474(7350): 212-215.
/
| 〈 |
|
〉 |
