目的  探讨检测多肽-N乙酰氨基半乳糖转移酶10（pp GalNAc-T10）单细胞技术与应用蛋白在肺癌、乳腺癌和结肠癌中的表达。  方法  采用免疫组织化学检测ppGalNAc-T10在110例肺癌组织、100例乳腺癌组织和110例结肠癌组织中的表达；不同的肿瘤均有10例相对应的正常组织作为对照。  结果  同正常肺组织相比较，ppGalNAc-T10在肺癌组织中表达较低；且ppGalNAc-T10的表达与肿瘤侵袭深度相关(P<0.01)。PpGalNAc-T10蛋白在乳腺癌和结肠癌及其相对应的正常组织的表达差异无显著性。  结论  PpGalNAc-T10在肺癌中，有可能成为的1个有效标记蛋白。

Objective The purpose of this study is to investigate the expression of the polypeptide N-acetylgalactosaminyltransferase-10(ppGalNAc-T10) protein in lung and breast and colon cancer.  Methods  Immunohistochemistry was used to analyse ppGalNAc-T10 expressions in 110 lung cancer tissues, 100 breast cancer tissues and 110 colon cancer tissues. Meanwhile, different cancer has 10 cases of normal tissues as control.   Results  The expression of ppGalNAc-T10 in normal lung tissue was higher compared with that in lung cancer organizations, and ppGalNAc-T10 positive expression was found to be significantly associated with invasion depth of tumor (P<0.01). PpGalNAc-T10 protein expression in breast and colon cancer was no significantly difference than that in non-tumor breast and colon tissue.   Conclusion  PpGalNAc-T10 expression is a useful marker in lung cancer.