利用基因芯片技术研究FGFR3在小鼠胚胎肢芽不同发育阶段的表达

唐欣; 余从年; 杨述华; 陈雨辰; 李奇; 杨操; 李进; 许伟华

解剖学报 ›› 2008, Vol. 39 ›› Issue (6) : 890-893.

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利用基因芯片技术研究FGFR3在小鼠胚胎肢芽不同发育阶段的表达

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FGFR3 EXPRESSION PATTERN DURING THE DEVELOPMENT OF MOUSE EMBRYONAL LIMB BUD DETECTED BY MICROARRAY ANALYSIS

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Abstract

Objective To study the expression pattern of fibroblast growth factor receptor 3(FGFR3) in mouse embryonal limb bud development. Methods Affymetrix mouse 430 2.0 cDNA was used with microarray technique to examine the 34 000 genes. Histology staining observation was performed at the same time. Results FGFR3 expression was enhanced obviously in mouse E12.5d embryonal limb bud. It continued to increase and peaked in mouse E13.5d embryonal limb bud. Furthermore, the expression down-regulated gradually from E14.5d in mouse embryonal limb bud. Conclusion The expression of FGFR3 has close correlation with chondrogenesis of mouse embryonal limb bud. FGFR3 may play an important role in chondrogenesis.

导出引用

唐欣;余从年;杨述华;陈雨辰;李奇;杨操;李进;许伟华. 利用基因芯片技术研究FGFR3在小鼠胚胎肢芽不同发育阶段的表达[J]. 解剖学报. 2008, 39(6): 890-893

FGFR3 EXPRESSION PATTERN DURING THE DEVELOPMENT OF MOUSE EMBRYONAL LIMB BUD DETECTED BY MICROARRAY ANALYSIS[J]. Acta Anatomica Sinica. 2008, 39(6): 890-893

中图分类号： Q344